Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet
Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet
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DOI：
10.1016/j.foodchem.2012.06.034
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发表时间：
2012-12-01
期刊：
影响因子：
8.8
通讯作者：
Ahmedna, Mohamed
中科院分区：
文献类型：
--
作者：
Bansode, Rishipal R.;Randolph, Priscilla;Ahmedna, Mohamed
研究了花生皮水溶性多酚提取物（PE）对西式饮食大鼠降血脂作用的影响。七周龄的Wistar大鼠接受对照饮食（AIN-93 G）、具有和不具有PE推注的西方饮食，每周五次，持续10周。接受300 mg/kg体重的组显示体重和附睾脂肪显着减少。血浆和肝脏甘油三酯（TG）和胆固醇（TC）水平显著降低，粪便中TG和TC的分泌显著增加，肝脏中参与脂肪酸合成的酶（如脂肪酸合成酶（FAS）、固醇受体元件结合蛋白（SREBP）-1c、乙酰辅酶A羧化酶（ACC 1））和脂质摄取基因（如PPAR γ）的mRNA表达降低，而PPARalpha则被PE上调。这些数据表明，PE给药可能有助于改善高胆固醇和高脂质饮食大鼠的脂质体内平衡。(C)2012爱思唯尔有限公司保留所有权利。
The effect of water soluble polyphenolic extract of peanut skin (PE) was investigated for its hypolipidemic properties in rats on Western diet. Seven-weeks old Wistar rats received control diet (AIN-93G), Western diet with and without a bolus of PE five times a week for 10 weeks. Group which received 300 mg/kg body weight showed significantly reduced body weight and epididymal fat. Plasma and liver triglyceride (TG) and cholesterol (TC) levels were significantly reduced while faecal secretion of TG and TC was greatly increased upon PE administration.Liver mRNA expression of enzymes involved in fatty acid synthesis, such as fatty acid synthase (FAS), sterol receptor element binding protein (SREBP)-1c, acetyl-CoA carboxylase (ACC1) and lipid uptake genes, such as PPAR gamma, were decreased, while PPAR alpha was up-regulated by administration of PE. These data suggest that administration of PE may contribute to the improved lipid homoeostasis in rats on diets high in cholesterol and lipids. (C) 2012 Elsevier Ltd. All rights reserved.