Characteristics of an ovariectomized osteopenic rat model
Characteristics of an ovariectomized osteopenic rat model
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DOI：
10.1002/jbmr.5650040104
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发表时间：
1989-02
影响因子：
6.2
通讯作者：
I. Yamazaki;H. Yamaguchi
中科院分区：
文献类型：
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作者：
I. Yamazaki;H. Yamaguchi
尽管卵巢切除术（Ovx）诱导的大鼠骨质疏松症已被广泛用作人类绝经后骨质疏松症的模型，但不同研究者的研究结果并不总是一致的。这可能主要是由于Ovx时动物的年龄、Ovx后的时间和测量的变量存在差异。因此，在本研究中，在4、10或52周时进行Ovx，并在大鼠中观察6个月的骨变化。Ovx对体重、股骨长度和股骨体积的影响在4周龄手术的大鼠中显著，在52周龄手术的大鼠中轻微，在10周龄手术的大鼠中中等。仅在52周龄时切除卵巢的大鼠中观察到股骨中段皮质厚度与骨宽度的比值降低。所有大鼠的股骨比重和股骨干骺端密度在OVX后均降低。股骨的灰分重量与干重的比率（骨正常钙化的量度）在Ovx后不久没有变化，但在所有大鼠中逐渐降低。
Although osteoporosis induced by ovariectomy (Ovx) in the rat has been widely used as a model for postmenopausal osteoporosis in humans, the findings of different investigators are not always consistent. This might be mainly due to differences in the age of the animals at Ovx, time after Ovx, and the variables measured. Therefore, in the present study, Ovx was performed at 4, 10, or 52 weeks and bone changes were observed in rats for 6 months. The effects of Ovx on body weight, femoral length, and femoral volume were marked in rats operated on at the age of 4 weeks, slight in rats operated on at the age of 52 weeks, and intermediate in rats operated on at the age of 10 weeks. A reduction in the ratio of cortical thickness to bone width at the midshaft of the femur was observed only in rats ovariectomized at 52 weeks of age. The specific gravity of the femur and the density of the metaphysis of the femur decreased after Ovx in all rats. The ratio of ash weight to dry weight of the femur, a measure of the normal calcification of bone, was unchanged shortly after Ovx but gradually decreased in all rats.