The Study of Left Ventricular Function in Man by Increasing Resistance to Ventricular Ejection with Angiotensin
The Study of Left Ventricular Function in Man by Increasing Resistance to Ventricular Ejection with Angiotensin
复制标题
血管紧张素增加心室射血阻力对人体左心室功能的研究
作者：
J. Ross;E. Braunwald
通过测定分级输注血管紧张素增加左心室射血阻力的效果，对18例患者的左心室性能进行了研究。通过这种方式，左心室功能曲线，即，建立心室舒张末期压与每搏作功的关系。在无左心室疾病的患者中，心室功能曲线表现出陡峭的上升分支，在左心室舒张末期压小幅升高的情况下发生搏出功的大幅增加;相反，在有心脏疾病的患者中，心室功能曲线要么是平坦的，即，心搏作功的微小变化伴随左心室舒张末期压的大幅升高，或功能曲线呈现下降的肢体。在血管紧张素输注前，许多左室功能曲线有或无压低的患者左室舒张末期压和每搏作功值相当。因此，血管紧张素试验可用于检测心肌功能损害和以定量形式表达损害的严重程度。
The performance of the left ventricle was studied in 18 patients by determining the effects of increasing the resistance to left ventricular ejection with graded infusions of angiotensin. By this means, left ventricular function curves, i.e., the relationship between ventricular end-diastolic pressure and stroke work, were constructed. In patients without left ventricular disease the ventricular function curves exhibited steep ascending limbs, large increases in stroke work occurring with small elevations of left ventricular end-diastolic pressure; in contrast, in patients with cardiac disease, the ventricular function curves were either flat, i.e., small changes in stroke work occurred with large elevations in left ventricular end-diastolic pressure, or the function curves exhibited descending limbs. Prior to the infusion of angiotensin many patients with and without depression of their left ventricular function curves had comparable values ofleft ventricular end-diastolic pressure and stroke work. Thus, the angiotensin test may prove useful for detecting impairment of myocardial function and for expressing the severity of the impairment in a quantitative form.