Superficial and juxtamedullary nephron function during saline loading in the dog.
Superficial and juxtamedullary nephron function during saline loading in the dog.
复制标题
狗盐水负荷期间浅表肾单位和近髓肾单位的功能。
DOI：
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发表时间：
1974
影响因子：
15.9
通讯作者：
N. Levinsky
中科院分区：
文献类型：
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作者：
F. Bruns;E. Alexander;A. L. Riley;N. Levinsky
用改良的Hanssen显微解剖技术测定对照组和生理盐水扩张组的浅层肾单位滤过率(SNGFR)和髓旁肾单位滤过率(JMGFR)。在对照研究中，SNGFR为60+/-4，JMGFR为72+/-5nL/min。生理盐水负荷时，SNGFR为74+/-8，JMGFR为65+/-6nL/min。SNGFR：JMGFR的比值从0.84+/-0.03增加到1.15+/-0.08。用微球法测定对照组和生理盐水负荷时的肾小球灌注率(GPR)。浅层GPR无明显变化，髓旁GPR由225+/-42增至323+/-39nL/min。计算的浅层肾单位滤过分数在生理盐水扩张后没有变化，但髓旁滤过分数从0.34+/-0.07下降到0.24+/-0.07。数据显示滤过向肾皮质浅层转移和血浆流向肾皮质深层的趋势。与浅层肾单位相比，延髓旁肾单位的GFR对血浆流量的依赖程度较低。皮质深层滤过分数的下降可能影响延髓旁肾单位的钠排泄。
A modification of the microdissection technique of Hanssen was utilized in dogs to measure superficial (SNGFR) and juxtamedullary nephron filtration rate (JMGFR) in control and saline-expanded dogs. During control studies SNGFR was 60+/-4 and JMGFR was 72+/-5 nl/min. During saline loading SNGFR was 74+/-8 and JMGFR was 65+/-6 nl/min. The ratio SNGFR: JMGFR significantly increased from 0.84+/-0.03 to 1.15+/-0.08. Glomerular perfusion rate (GPR) was measured with the microsphere method during control and saline loading. Superficial GPR did not change significantly but juxtamedullary GPR increased from 225+/-42 to 323+/-39 nl/min. Calculated superficial nephron filtration fraction was unchanged after saline expansion but juxtamedullary filtration fraction decreased from 0.34+/-0.07 to 0.24+/-0.07. The data demonstrate a tendency for filtration to shift toward the superficial part and plasma flow toward the deep part of the kidney cortex. GFR in juxtamedullary nephrons appears to be less plasma flow-dependent than in superficial nephrons. The fall in filtration fraction in the deep cortex may affect sodium excretion by juxtamedullary nephrons.