Reading affect in the face and voice - Neural correlates of interpreting communicative intent in children and adolescents with autism spectrum disorders
Reading affect in the face and voice - Neural correlates of interpreting communicative intent in children and adolescents with autism spectrum disorders
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DOI：
10.1001/archpsyc.64.6.698
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发表时间：
2007-06-01
影响因子：
--
通讯作者：
Dapretto, Mirella
中科院分区：
文献类型：
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作者：
Wang, A. Ting;Lee, Susan S.;Dapretto, Mirella
内容：在日常互动中，理解说话者的交际意图很可能会利用面部表情和语调等线索。先前的研究表明，自闭症谱系障碍（ASD）患者的大脑区域活动减少，这些区域选择性地对面部和声音做出反应。然而，也有证据表明，如果任务要求允许情绪的外显处理，关键区域的活动可以增加。目标：以反语理解为测试案例，研究ASD患者在解释交际意图时的神经回路损伤，并确定明确的面部表情和语调指示是否会引起更规范的大脑活动模式。设计，设置，和参与者：在洛杉矶的加州大学Ahmanson-Lovelace脑成像中心，18名ASD男孩（年龄7-17岁，全面智商> 70）和18名正常发育（TD）男孩接受了功能性磁共振成像。行为表现（准确性和反应时间）也recorded.Results：减少活动在内侧前额叶皮层和右上级颞回观察到ASD儿童相对TD儿童在感知潜在的讽刺与控制方案。重要的是，一个显着的X组条件的相互作用，在内侧前额叶皮层表明，活动调制的明确指示，参加面部表情和语调，只有在ASD组。最后，内侧前额叶皮层的活动呈负相关的自闭症儿童的症状严重程度，使儿童更大的社会障碍表现出较少的活动在这个region.Conclusions：明确的指示，参加面部表情和语调的声音可以引起增加活动的内侧前额叶皮层，一个网络的一部分，重要的是了解他人的意图，在自闭症儿童。这些发现为未来的干预研究提供了策略。
Context: Understanding a speaker's communicative intent in everyday interactions is likely to draw on cues such as facial expression and tone of voice. Prior research has shown that individuals with autism spectrum disorders (ASD) show reduced activity in brain regions that respond selectively to the face and voice. However, there is also evidence that activity in key regions can be increased if task demands allow for explicit processing of emotion.Objectives: To examine the neural circuitry underlying impairments in interpreting communicative intentions in ASD using irony comprehension as a test case, and to determine whether explicit instructions to attend to facial expression and tone of voice will elicit more normative patterns of brain activity.Design, Setting, and Participants: Eighteen boys with ASD (aged 7-17 years, full-scale IQ > 70) and 18 typically developing (TD) boys underwent functional magnetic resonance imaging at the Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles.Main Outcome Measures: Blood oxygenation level-dependent brain activity during the presentation of short scenarios involving irony. Behavioral performance (accuracy and response time) was also recorded.Results: Reduced activity in the medial prefrontal cortex and right superior temporal gyrus was observed in children with ASD relative to TD children during the perception of potentially ironic vs control scenarios. Importantly, a significant group X condition interaction in the medial prefrontal cortex showed that activity was modulated by explicit instructions to attend to facial expression and tone of voice only in the ASD group. Finally, medial prefrontal cortex activity was inversely related to symptom severity in children with ASD such that children with greater social impairment showed less activity in this region.Conclusions: Explicit instructions to attend to facial expression and tone of voice can elicit increased activity in the medial prefrontal cortex, part of a network important for understanding the intentions of others, in children with ASD. These findings suggest a strategy for future intervention research.