Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes.
Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes.
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DOI：
10.3390/ma9010029
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发表时间：
2016-01-06
期刊：
影响因子：
--
通讯作者：
Reimhult E
中科院分区：
文献类型：
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作者：
Bixner O;Kurzhals S;Virk M;Reimhult E
通过两亲性嵌段共聚物聚（异戊二烯-b-N-异丙基丙烯酰胺）与单分散疏水性超顺磁性氧化铁纳米粒子（SPION）的自组装，制备了磁性高分子囊泡。特别设计的温敏嵌段共聚物允许在膜芯中有效地掺入疏水纳米颗粒并在囊泡的内腔中包封水溶性染料钙黄绿素。磁加热的嵌入SPION导致通过脱水的热敏PNIPAM块的双层渗透性增加。因此，仅通过暴露于交变磁场的脉冲，就可以以受控剂量释放捕获的钙黄绿素。这种混合SPION-聚合物囊泡系统展示了释放应用的可能方向，其将合理的聚合物囊泡设计与通过嵌入的纳米材料的外部磁场触发释放相结合。
Magnetic polymersomes were prepared by self-assembly of the amphiphilic block copolymer poly(isoprene-b-N-isopropylacrylamide) with monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPION). The specifically designed thermoresponsive block copolymer allowed for efficient incorporation of the hydrophobic nanoparticles in the membrane core and encapsulation of the water soluble dye calcein in the lumen of the vesicles. Magnetic heating of the embedded SPIONs led to increased bilayer permeability through dehydration of the thermoresponsive PNIPAM block. The entrapped calcein could therefore be released in controlled doses solely through exposure to pulses of an alternating magnetic field. This hybrid SPION-polymersome system demonstrates a possible direction for release applications that merges rational polymersome design with addressed external magnetic field-triggered release through embedded nanomaterials.