Age-specific metabolic rates and mortality rates in the genus Drosophila.
Age-specific metabolic rates and mortality rates in the genus Drosophila.
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果蝇属的年龄特异性代谢率和死亡率。
DOI：
10.1046/j.1474-9728.2002.00009.x
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发表时间：
2002
期刊：
影响因子：
7.8
通讯作者：
Haselkorn,TamaraS
中科院分区：
文献类型：
--
作者：
Promislow,DanielEL;Haselkorn,TamaraS
早期的衰老理论表明，代谢率相对较高的生物体寿命较短。尽管这一老龄化的“存活率”理论得到了广泛的检验，但几乎没有经验证据支持这一观点。一种更细粒度的方法可以检查与年龄相关的代谢率在一生中的变化，这可能为代谢率和衰老之间的关系提供有价值的见解。在这里，我们比较了果蝇属五种果蝇中与年龄相关的代谢率(以每小时产生的二氧化碳来衡量)和与年龄相关的死亡率。我们没有发现证据表明寿命较长的物种代谢率较低。在所有五个物种中，都没有明确的证据表明与年龄相关的新陈代谢下降。新陈代谢速率在整个生命过程中都是惊人的恒定的，除了雌性。海底氏，代谢率表现为在生命的前三分之一后增加，然后下降。我们认为，随着进化时间的推移，一些生理特征可能已经被如此强烈的选择所塑造，以至于它们对单个个体一生中发生的选择力量的下降相对具有抵抗力。我们认为，将没有衰老迹象的特定特征与那些随年龄下降的特征进行比较，可以提供对衰老过程的洞察。
Early theories of aging suggested that organisms with relatively high metabolic rates would live shorter lives. Despite widespread tests of this ‘rate of living’ theory of aging, there is little empirical evidence to support the idea. A more fine‐grained approach that examined age‐related changes in metabolic rate over the life span could provide valuable insight into the relationship between metabolic rate and aging. Here we compare age‐related metabolic rate (measured as CO2production per hour) and age‐related mortality rate among five species in the genusDrosophila. We find no evidence that longer‐lived species have lower metabolic rates. In all five species, there is no clear evidence of an age‐related metabolic decline. Metabolic rates are strikingly constant throughout the life course, with the exception of females ofD. hydei, in which metabolic rates show an increase over the first third of the life span and then decline. We argue that some physiological traits may have been shaped by such strong selection over evolutionary time that they are relatively resistant to the decline in the force of selection that occurs within the life time of a single individual. We suggest that comparisons of specific traits that do not show signs of aging with those traits that do decline with age could provide insight into the aging process.