Regulation of uterine responsiveness to injected estradiol in nutritionally stressed ovariectomized rats by adrenal-dervied estradiol.
Regulation of uterine responsiveness to injected estradiol in nutritionally stressed ovariectomized rats by adrenal-dervied estradiol.
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通过肾上腺衍生的雌二醇调节营养应激的卵巢切除大鼠的子宫对注射雌二醇的反应。
作者：
T. T. Hung;K. Barker
研究了雌二醇诱导成熟去卵巢大鼠子宫葡萄糖-6-脱氢酶（G6PD）活性的影响。与饲喂基础日粮相比，饥饿5 d和饲喂无纯化蛋白日粮3 d可显著提高子宫G6PD活性。随着日粮中酪蛋白含量从0-45%增加，酶的诱导能力下降，24小时内重新饲喂蛋白质开始逆转蛋白质剥夺对酶的诱导能力的影响。饮食或饥饿对子宫G6PD活性的基础水平没有影响，雌二醇对饥饿和/或蛋白质剥夺大鼠诱导能力的增强是由于G6PD合成的相对新生率增加了2倍。在饥饿和/或缺乏蛋白质的大鼠体内给予[3H]雌二醇的子宫结合和潴留增加了40%，这种增加似乎是由于雌二醇含量的增加。
The effects of diet composition and starvation on the inducibility by estradiol of uterine glucose-6-dehydrogenase (G6PD) activity in mature ovariectomized rats has been evaluated. Starvation for 5 days and feeding a purified protein-free diet for 3 days caused a maximal increase in the inducibility of uterine G6PD activity relative to animals fed a basal diet. Inducibility of the enzyme was decreased as the amount of casein in the diet was increased from 0–45% and refeeding protein began to reverse the effect of protein deprivation on the inducibility of the enzyme within 24 h. The basal level of uterine G6PD activity was unchanged by diet or starvation, and the increased inducibility by estradiol in starved and/or proteindeprived rats was due to a 2-fold increase in the relative de novo rate of G6PD synthesis. The uterine binding and retention of [3H]estradiol given in vivo was increased by 40% in starved and/ or protein-deprived rats, and this increase appeared to be due to an increase in the estradiol...