New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets.
New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets.
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DOI：
10.1089/15209150050502023
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发表时间：
2000-12
影响因子：
5.4
通讯作者：
T. Gardner;D. Antonetti;A. Barber;K. Lanoue;Makoto Nakamura
中科院分区：
文献类型：
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作者：
T. Gardner;D. Antonetti;A. Barber;K. Lanoue;Makoto Nakamura
糖尿病视网膜病变是视力损害的主要原因，其经典定义为血管病变。本文综述了糖尿病如何影响血管细胞，以及神经元，大胶质细胞和小胶质细胞。糖尿病视网膜病变的细胞和临床因素具有许多慢性炎症的特征。了解视网膜中的个体细胞特异性和全局炎症变化可能会导致新的治疗方法来预防视力丧失。
Diabetic retinopathy, a leading cause of vision impairment, is classically defined by its vascular lesions. This review examines how diabetes affects vascular cells, as well as neurons, macroglia, and microglia. The cellular and clinical elements of diabetic retinopathy have many features of chronic inflammation. Understanding the individual cell-specific and global inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss.