Quantifying blood flow dynamics during cardiac development: demystifying computational methods
Quantifying blood flow dynamics during cardiac development: demystifying computational methods
复制标题
DOI：
10.1098/rstb.2017.0330
复制
发表时间：
2018-11-05
影响因子：
6.3
通讯作者：
Rugonyi, Sandra
中科院分区：
文献类型：
--
作者：
Courchaine, Katherine;Rugonyi, Sandra
血流条件（血液动力学）对心血管的正常发育至关重要。事实上，血流诱导生物力学适应和机械转导信号，影响胚胎期及以后的心血管生长和发育。血流条件改变是先天性心脏病的标志，并且已知在早期胚胎阶段血流中断会导致先天性心脏畸形。尽管如此，血流力学影响心血管发育的许多机制仍然未知。这部分是由于量化血流动力学和血流对发育中的心血管组织施加的力所涉及的挑战。然而，最近的技术即使在胚胎早期也可以精确测量血流参数和心血管几何形状。结合计算流体动力学技术，可以量化血液动力学参数及其在发育过程中的变化，这是寻求理解机械线索对心脏和血管形成的作用的关键一步。这项研究总结了血流动力学建模的一些基本方面，重点是三维建模技术，并讨论了相关研究，揭示了血流的细节及其对心血管发育的影响。
Blood flow conditions (haemodynamics) are crucial for proper cardiovascular development. Indeed, blood flow induces biomechanical adaptations and mechanotransduction signalling that influence cardiovascular growth and development during embryonic stages and beyond. Altered blood flow conditions are a hallmark of congenital heart disease, and disrupted blood flow at early embryonic stages is known to lead to congenital heart malformations. In spite of this, many of the mechanisms by which blood flow mechanics affect cardiovascular development remain unknown. This is due in part to the challenges involved in quantifying blood flow dynamics and the forces exerted by blood flow on developing cardiovascular tissues. Recent technologies, however, have allowed precise measurement of blood flow parameters and cardiovascular geometry even at early embryonic stages. Combined with computational fluid dynamics techniques, it is possible to quantify haemodynamic parameters and their changes over development, which is a crucial step in the quest for understanding the role of mechanical cues on heart and vascular formation. This study summarizes some fundamental aspects of modelling blood flow dynamics, with a focus on three-dimensional modelling techniques, and discusses relevant studies that are revealing the details of blood flow and their influence on cardiovascular development.This article is part of the Theo Murphy meeting issue 'Mechanics of development'.