Primary Graft Dysfunction
Primary Graft Dysfunction
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DOI：
10.1016/j.ccm.2011.02.007
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发表时间：
2011-06-01
影响因子：
5.7
通讯作者：
Christie, Jason D.
中科院分区：
文献类型：
--
作者：
Lee, James C.;Christie, Jason D.
原发性移植物功能障碍（PGD）是肺移植术后早期发病和死亡的最重要原因。PGD影响高达25%的所有肺移植手术，目前尚无经证实的预防性治疗。从PGD中恢复的肺移植受者可能有长期功能受损和闭塞性细支气管炎综合征的风险增加。本文旨在提供一个国家的最先进的审查PGD流行病学，结果和危险因素，并总结目前的努力，生物标志物的发展和新的战略，预防和治疗。
Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis obliterans syndrome. This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment.