Iron-Facilitated Direct Oxidative C-H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles
Iron-Facilitated Direct Oxidative C-H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles
复制标题
铁促进烯丙基芳烃或烯烃直接氧化 C-H 转化为烯基腈
DOI：
10.1021/ja1070202
复制
发表时间：
2010-11-17
影响因子：
15
通讯作者：
Jiao, Ning
中科院分区：
文献类型：
--
作者：
Qin, Chong;Jiao, Ning
本文描述了第一种通过廉价的均相铁催化剂由烯丙基芳烃或烯烃直接制备烯基腈的方法。在此过程中，在温和的条件下发生了三次C-H键断裂。机理研究表明，烯丙基C（sp（3））-H键的断裂参与的速率控制步骤。这一观察结果可能提供了一个机会，以实现C（sp（3））-H功能化催化的铁催化剂。
This paper describes the first direct approach to alkenyl nitriles from allylarenes or alkenes facilitated by an inexpensive homogeneous iron catalyst. Three C-H bond cleavages occur under the mild conditions during this process. Mechanistic studies indicate that the cleavage of the allyl C(sp(3))-H bond is involved in the rate-determining step. This observation may provide an opportunity to achieve C(sp(3))-H functionalization catalyzed by an iron catalyst.