The Odense Child Cohort: Aims, Design, and Cohort Profile
The Odense Child Cohort: Aims, Design, and Cohort Profile
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DOI：
10.1111/ppe.12183
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发表时间：
2015-05-01
影响因子：
2.8
通讯作者：
Husby, Steffen
中科院分区：
文献类型：
--
作者：
Kyhl, Henriette Boye;Jensen, Tina Kold;Husby, Steffen
背景环境对胎儿和婴儿整个生命早期发育的重要性越来越被认识到。为了研究这些影响，需要生物样本和准确的数据记录。欧登塞儿童队列（OCC）研究基于从健康孕妇人群中收集的多项数据，旨在通过对2010年至2012年出生的儿童进行连续随访至18岁，提供有关环境对儿童健康影响的新信息。自那以后，有374人离开了研究，剩下2500个活跃的家庭。非参与者作为对照，通过本地登记中心提供数据。对生物材料、调查问卷和登记数据进行了汇编。人体测量数据和其他物理data.Results2500个家庭积极参与了这项研究，2549名儿童。64%的父亲和60%和58%的母亲分别在怀孕10周和28周时捐献了血液样本。平均而言，69%的儿童完成了问卷调查，78%的儿童定期接受检查，并采集了血液样本（46%）。参与的孕妇与非参与者在几个方面有所不同：年龄、体重指数、吸烟、产次、教育程度和种族。婴儿的性别和方式的deliver.ConclusionsThe OCC提供的材料进行深入分析的环境和遗传因素，是重要的儿童健康和疾病。可获得未参与研究的妇女和婴儿的登记数据，确保数据具有高度可比性。
BackgroundThe importance of the environment on the development of the fetus and infant throughout early life is increasingly recognised. To study such effects, biological samples and accurate data records are required. Based on multiple data collection from a healthy pregnant population, the Odense Childhood Cohort (OCC) study aims to provide new information about the environmental impact on child health by sequential follow-up to 18 years of age among children born between 2010 and 2012.MethodsA total of 2874 of 6707 pregnancies (43%) were recruited between January 2010 and December 2012. Three hundred seventy-four have since left the study, leaving 2500 active families. The non-participants act as controls contributing data through local registries. Biological material, questionnaires, and registry data were compiled. Anthropometric data and other physical data were collected.ResultsTwo thousand five hundred families actively participated in the study with 2549 children. Sixty-four percent of the fathers and 60% and 58% of the mothers, respectively, donated a blood sample at 10 and 28 weeks of gestation. On average, 69% completed questionnaires, 78% of the children were regularly examined, and had a blood sample taken (46%). The participating pregnant women differed from the non-participants in several respects: age, body mass index, smoking, parity, education, and ethnicity. The infants were comparable with respect to gender and mode of delivery.ConclusionsThe OCC provides material for in-depth analysis of environmental and genetic factors that are important for child health and disease. Registry data from non-participating women and infants are available which ensures a high degree of comparable data.