ANNA-2: An antibody associated with paraneoplastic opsoclonus in a patient with large-cell carcinoma of the lung with neuroendocrine features - Correlation of clinical improvement with tumor response
ANNA-2: An antibody associated with paraneoplastic opsoclonus in a patient with large-cell carcinoma of the lung with neuroendocrine features - Correlation of clinical improvement with tumor response
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DOI：
10.1081/cnv-120030214
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Alrajab, S
中科院分区：
文献类型：
--
作者：
Erlich, R;Morrison, C;Alrajab, S
本报告描述一个具有神经内分泌特征的大细胞肺癌病例，其临床表现为副肿瘤性眼阵挛-肌阵挛综合征。患者在接受对症治疗后，神经功能障碍意外地戏剧性消退。症状改善的同时，血清安娜-2抗体滴度逐渐下降至检测不到的水平。
This report describes a case of large-cell lung carcinoma with neuroendocrine features, presenting with the full clinical picture of paraneoplastic opsoclonus-myoclonus syndrome. The patient had an unexpectedly dramatic resolution of the neurologic dysfunction after receiving antineoplastic treatment. Symptom improvement paralleled a progressive decline of serum ANNA-2 antibody titers to undetectable levels.