Sensitization of the mesoaccumbens dopamine response to nicotine
Sensitization of the mesoaccumbens dopamine response to nicotine
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DOI：
10.1016/s0091-3057(97)00537-6
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发表时间：
1998-04-01
影响因子：
3.6
通讯作者：
Al-Aloul, M
中科院分区：
文献类型：
--
作者：
Balfour, DJK;Benwell, MEM;Al-Aloul, M
本文综述了尼古丁预处理对多巴胺（DA）系统的刺激作用具有区域选择性敏化作用的证据，它与尼古丁的运动刺激反应有关，每日注射尼古丁诱发的致敏作用与中脑DA神经元控制的区域选择性下调有关通过抑制性自身受体，并依赖于共刺激的NMDA受体。有人建议，敏化有关的mesoadrenbens神经元，这导致在增强DA释放到细胞外间隙之间的细胞，它的作用在假定的突触外多巴胺受体增强突发发射。用NMDA受体拮抗剂的研究揭示了致敏的中脑DA的表达与对尼古丁的运动反应之间的分离。因此，我们认为，对尼古丁的致敏多巴胺反应可能与对与尼古丁依赖更密切相关的药物的精神药理学反应有关。(C)1998年爱思唯尔科学公司
This article reviews the evidence that pretreatment with nicotine causes a regionally selective sensitization of its stimulatory effects on a pathway, the mesoaccumbens dopamine (DA) system, which has been implicated in the locomotor stimulant response to nicotine and its ability to reinforce self-administration The sensitization evoked by daily injections of nicotine is associated with a regionally selective downregulation of the control of mesoaccumbens DA neurons by inhibitory autoreceptors and depends upon co-stimulation of NMDA glutamatergic receptors. It is suggested that the sensitization is related to enhanced burst firing of mesoaccumbens neurons, which results in an enhancement of DA release into the extracellular space between the cells where it acts upon putative extrasynaptic dopamine receptors. The studies with NMDA receptor antagonists revealed a dissociation between the expression of sensitized mesoaccumbens DA and locomotor responses to nicotine. It is proposed, therefore, that the sensitized mesoaccumbens DA responses to nicotine may be implicated in psychopharmacological responses to drug concerned more closely with nicotine dependence. (C) 1998 Elsevier Science Inc.