Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer
Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer
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DOI：
10.1387/ijdb.120134jd
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发表时间：
2012-01-01
影响因子：
0.7
通讯作者：
Rame, Christelle
中科院分区：
文献类型：
--
作者：
Dupont, Joelle;Reverchon, Maxime;Rame, Christelle
控制能量平衡的生理机制与控制生殖的生理机制紧密相连，这些机制共同优化了波动代谢条件下的生殖成功。脂肪组织在这种调节中起着重要作用。事实上，它释放了各种各样的因子，称为脂肪因子，调节能量代谢，也调节生殖功能。现就脂肪细胞因子的功能及其调控机制作一综述（瘦素，脂联素，脂联素，内脂素，chemerin和apelin）参与卵泡发育。卵泡似乎使用各种“营养感应”机制，可能形成营养状态和卵泡发生之间的联系。本文综述了可能感觉卵泡内营养流的途径，包括PI 3 K/Akt通路、腺苷一磷酸激活激酶（AMPK）和过氧化物酶体增殖物激活受体（PPARs）。它还审查了目前的信息，这些脂肪因子和信号通路在卵巢癌中的作用。
The physiological mechanisms that control energy balance are reciprocally linked to those that control reproduction, and together, these mechanisms optimize reproductive success under fluctuating metabolic conditions. Adipose tissue plays an important role in this regulation. Indeed, it releases a variety of factors, termed adipokines that regulate energy metabolism, but also reproductive functions. This article summarizes the function and regulation of some better-characterized adipokines (leptin, adiponectin, resistin, visfatin, chemerin and apelin) involved in ovarian follicle development.The follicle appears to use various "nutrient sensing" mechanisms that may form the link between nutrient status and folliculogenesis.This review examines evidence for the presence of pathways that may sense nutrient flux from within the follicle including the PI3K/ Akt pathway, adenosine monophosphate-activated kinase (AMPK), and peroxisome proliferator-activated receptors (PPARs). It also reviews current information on the role of these adipokines and signalling pathways in ovarian cancers.