Structure and total synthesis of lysobactin (katanosin B).

Structure and total synthesis of lysobactin (katanosin B).
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DOI:
10.1002/anie.200604232
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发表时间:
2007-03
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通讯作者:
F. von Nussbaum;S. Anlauf;J. Benet‐Buchholz;D. Häbich;J. Köbberling;L. Musza;J. Telser;H. Rübsamen-Waigmann;N. Brunner
F. von Nussbaum;S. Anlauf;J. Benet‐Buchholz;D. Häbich;J. Köbberling;L. Musza;J. Telser;H. Rübsamen-Waigmann;N. Brunner
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文献类型:
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作者:
F. von Nussbaum;S. Anlauf;J. Benet‐Buchholz;D. Häbich;J. Köbberling;L. Musza;J. Telser;H. Rübsamen-Waigmann;N. Brunner

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Scheme 1. Lariat structure of lysobactin (1), consisting of a dipeptidic linear segment (D-Leu1–Leu2) and a nonapeptidic cyclic segment (HyPhe3–Ser11). The depsipeptide 1 contains various nonribosomal amino acids. Atom-description indices based on amino acid residue and then atom number. HyLeu= threo-hydroxyleucine;[12] aThr= allothreonine; HyAsn= threo-β-hydroxyasparagine;[13] HyPhe= threo-βhydroxyphenylalanine, Boc= tert-butoxycarbonyl, Cbz= benzyloxycarbonyl.