Role of vitamin-K-dependent proteins in bone metabolism.
Role of vitamin-K-dependent proteins in bone metabolism.
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维生素 K 依赖性蛋白在骨代谢中的作用。
DOI：
10.1146/annurev.nu.08.070188.003025
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发表时间：
1988
影响因子：
8.9
通讯作者：
Price,PA
中科院分区：
文献类型：
--
作者：
Price,PA
这篇综述讨论了两种维生素 K 依赖性骨蛋白：骨 Gla 蛋白（骨钙素）和基质 Gla 蛋白的结构和可能的功能，以及通过分析这两种蛋白获得的维生素 K 作用机制的见解。两者均受 1,25-二羟基胆钙化醇调节，推测其功能与维生素 D 对骨骼的作用有关。目前，这两种蛋白质是除了参与凝血的蛋白质之外唯一被充分表征的维生素K依赖性脊椎动物蛋白质。
This review discusses the structure and possible functions of two vitamin K-dependent bone proteins, bone Gla protein (osteocalcin) and matrix Gla protein, and the insights into the mechanisms of vitamin K action that have been obtained by analysing those two proteins. Both are regulated by 1,25-dihydroxycholecalciferol and their functions are presumed to be linked to the actions of vitamin D on bone. At present, these two proteins are the only well-characterized vitamin K-dependent vertebrate proteins other than the proteins involved in blood coagulation.