The Mediator complex
The Mediator complex
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DOI：
10.1016/j.cub.2012.11.011
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发表时间：
2012-12
期刊：
影响因子：
9.2
通讯作者：
John Karijolich;M. Hampsey
中科院分区：
文献类型：
--
作者：
John Karijolich;M. Hampsey
是一个巨大的、多亚单位的蛋白质复合体，调节真核细胞中的基因表达。它就像一个分子电路板，整合了生理和发育信号，并将它们传输到RNA聚合酶II(POL II)，该酶负责转录所有编码蛋白质的基因。虽然Mediator最初被发现是激活剂依赖转录所必需的辅助因子，但它也刺激激活剂非依赖(基础)转录。此外，Mediator还可以作为辅助抑制因子，促进转录沉默。介体活性不仅限于它对转录启动的影响，它还可以影响延伸，甚至可能影响转录周期的所有阶段。
is an enormous, multi-subunit protein complex that regulates gene expression in eukaryotic cells. It acts as a molecular circuit board that integrates physiological and developmental signals and transmits them to RNA polymerase II (Pol II), the enzyme charged with transcription of all protein-encoding genes. Although initially discovered as a cofactor required for activatordependent transcription, Mediator also stimulates activator-independent (basal) transcription. Furthermore, Mediator can act as a co-repressor that facilitates transcriptional silencing. Mediator activity is not limited to its effects on transcription initiation, but it can also affect elongation and perhaps all stages of the transcription cycle.