Cause-specific mortality and cancer incidence rates in relation to urinary β2-microglobulin:: 23-Year follow-up study in a cadmium-polluted area
Cause-specific mortality and cancer incidence rates in relation to urinary β2-microglobulin:: 23-Year follow-up study in a cadmium-polluted area
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DOI：
10.1016/j.toxlet.2007.07.007
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发表时间：
2007-09-28
影响因子：
3.5
通讯作者：
Soda, Midori
中科院分区：
文献类型：
--
作者：
Arisawa, Kokichi;Uemura, Hirokazu;Soda, Midori
进行了一项纵向研究，调查环境镉（Cd）暴露与特定原因死亡率和癌症发病率的关系。研究人群包括275名生活在日本长崎县镉污染区的成年人。随访期从1982年至2005年，用于分析癌症死亡率，从1985年至2002年，用于分析癌症发病率。1980-1983年，由于镉污染稻田的恢复，研究区居民从食物中每日镉摄入量有所下降。尿β 2-微球蛋白（U-β 2 M）>= 1000 μ g/g肌酐的患者的死亡率显著高于日本人群中癌症以外原因的死亡率，但不是癌症（177，95%置信区间[CI] 94-303）。从镉污染地区的分析来看，与U-β 2 M增加相关的癌症死亡的年龄调整率比为2.58（95%CI 1.25-5.36）。U-β 2 M>= 1000 μ g/g肌酐的人群中癌症的发病率是地区参考率的1.38倍（95%CI 0.69-2.47）。在镉污染区，与高U-β 2 M相关的年龄校正癌症发生率比为1.79（95%CI 0.84-3.82）。总之，U-β 2 M排泄与癌症死亡率之间存在显著相关性。然而，尽管点估计值高于1，但癌症的标准化发病率没有显著增加，U-β 2 M与癌症发病率之间也没有显著关系。在得出暴露于环境镉和癌症风险之间的关联的结论之前，可能需要对更大的队列进行持续的随访和调查。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
A longitudinal study was performed to investigate the associations of exposure to environmental cadmium (Cd) with cause-specific mortality and cancer incidence rates. The study population comprised 275 adults living in a Cd-polluted area, Nagasaki Prefecture, Japan. The follow-up period extended from 1982 to 2005 for the analysis of cancer mortality, and from 1985 to 2002 for the analysis of cancer incidence. In the study area, the daily Cd intake from foods had decreased after 1980-1983 because of the restoration of Cd-polluted rice fields. The mortality rate among those with urinary beta 2-microglobulin (U-beta 2M) >= 1000 mu g/g creatinine was significantly higher than that of the Japanese population for death from causes other than cancer, but not for cancers (177 at the 95% confidence interval [CI] 94-303). From analysis within the Cd-polluted area, the age-adjusted rate ratio of cancer deaths associated with increased U-beta 2M was 2.58 (95% CI 1.25-5.36). The incidence rate of cancer among those with U-beta 2M >= 1000 mu g/g creatinine was 1.38 (95% CI 0.69-2.47) times that of the regional reference rate. Within the Cd-polluted area, the age-adjusted rate ratio of developing cancer associated with high U-beta 2M was 1.79 (95% CI 0.84-3.82). In summary, there was a significant association between U-beta 2M excretion and cancer mortality. However, there was neither a significantly increased standardized incidence ratio of cancer, nor significant relationship between U-beta 2M and cancer incidence rate, though the point estimates were higher than unity. Continued follow-up and investigation of a larger cohort may be required before drawing a conclusion for the association between exposure to environmental Cd and cancer risk. (C) 2007 Elsevier Ireland Ltd. All rights reserved.