Universal Protein Fluctuations in Populations of Microorganisms
Universal Protein Fluctuations in Populations of Microorganisms
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DOI：
10.1103/physrevlett.108.238105
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发表时间：
2012-06-06
影响因子：
8.6
通讯作者：
Braun, Erez
中科院分区：
文献类型：
--
作者：
Salman, Hanna;Brenner, Naama;Braun, Erez
任何蛋白质的拷贝数在群体中的细胞之间波动;表征和理解这些波动是生物物理学中的一个基本问题。我们在这里表明，在广泛的生物实现下测量的蛋白质分布崩溃到一个单一的非高斯曲线下缩放的前两个时刻。此外，在所有的实验中，方差被发现依赖于二次平均值，表明一个单一的自由度决定了整个分布。我们的研究结果表明，蛋白质的波动并不反映任何特定的分子或细胞机制，并建议一些缓冲过程掩盖这些细节，并诱导普遍性。
The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics. We show here that protein distributions measured under a broad range of biological realizations collapse to a single non-Gaussian curve under scaling by the first two moments. Moreover, in all experiments the variance is found to depend quadratically on the mean, showing that a single degree of freedom determines the entire distribution. Our results imply that protein fluctuations do not reflect any specific molecular or cellular mechanism, and suggest that some buffering process masks these details and induces universality.