GB virus C/Hepatitis G virus infection is frequent in American children and young adults.
GB virus C/Hepatitis G virus infection is frequent in American children and young adults.
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GB 丙型肝炎病毒/庚型肝炎病毒感染在美国儿童和年轻人中很常见。
DOI：
10.1086/313702
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Brown,KE
中科院分区：
文献类型：
--
作者：
Handa,A;Jubran,RF;Dickstein,B;Boylan,A;Luban,NL;Young,NS;Brown,KE
新的黄病毒GB病毒C/庚型肝炎病毒（GBV-C/HGV）已在美国约2%的献血者中检测到，并且在约9%的献血者中存在对包膜蛋白（E2）的中和抗体，这是先前感染GBV-C/HGV的标志物。美国儿童中GBV-C/HGV感染率尚不清楚。为了确定病毒感染是否可能发生在儿童时期，对160份来自无输血史的儿童和年轻人的血清标本（从血库样本中获得）进行了检测。分别在6.3%和9.4%的受试者中检测到病毒RNA和E2抗体。在13.8%的受试者中检测到既往或当前感染（病毒血症和/或E2抗体）的证据，表明GBV-C/HGV感染在美国儿童和年轻人中似乎很常见，即使在没有输血的情况下。
The novel flavivirus GB virus C/hepatitis G virus (GBV-C/HGV) has been detected in ∼2% of blood donors in the United States, and neutralizing antibody to the envelope protein (E2), a marker of previous infection with GBV-C/HGV, is present in ∼9% of donors. The rate of GBV-C/HGV infection among American children is unknown. To determine whether viral infection might occur during childhood, 160 serum specimens (obtained from blood bank samples) from children and young adults with no history of transfusion were tested. Viral RNA and antibody to E2 were detected in 6.3% and 9.4% of subjects, respectively. Evidence of previous or current infection (viremia and/or antibody to E2) was detected in 13.8% of subjects, indicating that GBV-C/HGV infection appears to be common among American children and young adults, even in the absence of blood transfusion.