Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques:: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection
Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques:: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection
复制标题
DOI：
10.1016/j.vaccine.2008.03.100
复制
发表时间：
2008-06-19
期刊：
影响因子：
5.5
通讯作者：
Robert-Guroff, Marjorie
中科院分区：
文献类型：
--
作者：
Florese, Ruth H.;Wiseman, Roger W.;Robert-Guroff, Marjorie
基于 HIV Tat 的疫苗对印度恒河猴和毛里求斯食蟹猴的保护作用有所不同。我们评估了这两个物种的天然 Tat 和 Ad-HIVtat 启动/Tat 增强方案。两种疫苗均具有免疫原性。只有 Ad-tat 方案可适度降低 SHIV89.6P 攻击后恒河猴的急性病毒血症。在毛里求斯猕猴中发现的混杂变量包括对 IB 类 MHC 和 II 类 H2 和 H5 单倍型感染的易感性以及对 IB 类单倍型 H3 和 H6 感染的抵抗力之间的显着关联。尽管保护作用有限，但结合了其他 HIV 成分的基于 Tat 的疫苗已显示出更大的功效。应进一步探索组合策略。由爱思唯尔有限公司出版
Protection afforded by HIV Tat-based vaccines has differed in Indian rhesus and Mauritian cynomolgus macaques. We evaluated native Tat and Ad-HIVtat priming/Tat-boosting regimens in both species. Both vaccines were immunogenic. Only the Ad-tat regimen modestly reduced acute viremia in rhesus macaques after SHIV89.6P challenge. Confounding variables uncovered in Mauritian macaques included significant associations of susceptibility to infection with MHC class IB and class II H2 and H5 haplotypes, and resistance to infection with class IB haplotypes H3 and H6. Although protection here was limited, Tat-based vaccines incorporating other HIV components have shown greater efficacy. Combination strategies should be further explored. Published by Elsevier Ltd.