Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021.
Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021.
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2002-2021年雷帕霉素哺乳动物靶点在神经科学领域的前景与热点
DOI：
10.3389/fnint.2022.940265
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发表时间：
2022
影响因子：
3.5
通讯作者：
Shang, Lei
中科院分区：
文献类型：
--
作者：
Li, Lijun;Xia, Xiaojing;Luo, Yunfeng;Zhu, Yuanting;Luo, Xuhong;Yang, Baolin;Shang, Lei
哺乳动物雷帕霉素靶蛋白（mTOR）是调节神经系统细胞代谢、生长和增殖的重要分子。本研究旨在通过文献计量学的方法，介绍mTOR通路在神经系统疾病中的研究热点，并预测其未来的发展趋势。我们参考了Web of Science Core Collection数据库中的出版物。使用VOSviewer和CiteSpace程序对国家/地区、机构、作者、期刊、关键词和引文进行评估，显示当前的研究重点，并预测mTOR在神经科学中的未来趋势。检索日期截止到2022年6月19日，共检索到2002年至2021年神经科学中关于mTOR的文章3,029篇。可视化分析显示，尽管部分年份的出版物数量略有下降，但与mTOR相关的出版物数量总体呈上升趋势，并在2021年达到峰值。它在美国拥有最多的出版物。关键词和文献分析表明，蛋白质合成调控、缺血、线粒体功能障碍、氧化应激、神经炎症等可能是mTOR研究的热点和未来方向。近年来，研究最多的神经系统疾病是阿尔茨海默病（AD）、结节性硬化症（TSC）和抑郁症，这些疾病仍值得研究者进一步研究。这为今后研究者在神经科学领域进一步研究mTOR提供了有益的参考。
Mammalian target of rapamycin (mTOR) is an important molecule that regulates cell metabolism, growth, and proliferation in the nervous system. This study aimed to present the current study hot spots and predict the future development trend of the mTOR pathway in neurologic diseases using bibliometrics. We referred to the publications in the Web of Science Core Collection database. VOSviewer and CiteSpace programs were used to evaluate countries/regions, institutions, authors, journals, keywords, and citations showing the current study focus and predicting the future trend of mTOR in neuroscience. The search date ended on 19 June 2022, and there were 3,029 articles on mTOR in neuroscience from 2002 to 2021. Visual analysis showed that although the number of publications declined slightly in some years, the number of publications related to mTOR generally showed an upward trend, reaching its peak in 2021. It had the largest number of publications in the United States. Keywords and literature analysis showed that protein synthesis regulation, ischemia, mitochondrial dysfunction, oxidative stress, and neuroinflammation may be hot spots and future directions of the nervous system in mTOR studies. Recently, the most studied neurological diseases are Alzheimer’s disease (AD), tuberous sclerosis complex (TSC), and depression, which are still worthy of further studies by researchers in the future. This can provide a useful reference for future researchers to study mTOR further in the field of neuroscience.
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影响因子：
3.4
作者：
Kingswood JC;Belousova E;Benedik MP;Budde K;Carter T;Cottin V;Curatolo P;Dahlin M;D'Amato L;d'Augères GB;de Vries PJ;Ferreira JC;Feucht M;Fladrowski C;Hertzberg C;Jozwiak S;Lawson JA;Macaya A;Marques R;Nabbout R;O'Callaghan F;Qin J;Sander V;Sauter M;Shah S;Takahashi Y;Touraine R;Youroukos S;Zonnenberg B;Jansen AC;TOSCA Consortium and TOSCA Investigators
通讯作者：
TOSCA Consortium and TOSCA Investigators
影响因子：
3.7
作者：
da Silva, Elizabeth Fidalgo;Botsford, Sabrina;Porter, Lisa A.
通讯作者：
Porter, Lisa A.
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
64.5
作者：
KUNZ, J;HENRIQUEZ, R;HALL, MN
通讯作者：
HALL, MN
影响因子：
3.8
作者：
Kondo S;Hirakawa H;Ikegami T;Uehara T;Agena S;Uezato J;Kinjyo H;Kise N;Yamashita Y;Tanaka K;Hasegawa N;Kiyuna A;Maeda H;Suzuki M;Gahana A
通讯作者：
Gahana A