Association Between High Serum Soluble Corin and Hypertension: A Cross-Sectional Study in a General Population of China
Association Between High Serum Soluble Corin and Hypertension: A Cross-Sectional Study in a General Population of China
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DOI：
10.1093/ajh/hpv002
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发表时间：
2015-09-01
影响因子：
3.2
通讯作者：
Zhang, Yonghong
中科院分区：
文献类型：
--
作者：
Peng, Hao;Zhang, Qiu;Zhang, Yonghong
背景基于细胞和动物的研究表明Corin与高血压有关。然而，该协会仍然缺乏基于人群的证据，这对促进基础研究向临床和预防实践的转化至关重要。在此，我们旨在探讨中国一般人群中的这种关联。方法2010年1月至5月，我们对居住在苏州姑苏区的2,498名30岁以上的参与者进行了横断面研究。测量血清可溶性corin和血压。 结果高血压参与者的血清corin水平高于非高血压参与者（中位数（四分位距）：1,836.83 (1,497.85-2,327.87) pg/ml vs. 1,579.14 (1,322.18-1,956.82) pg/ml，P < 0.001）。血清corin水平升高与高血压患病率呈正相关（比值比（OR）= 2.01，P < 0.001）。在多重分析中，与血清corin最低四分位数的参与者相比，第三四分位数（OR = 1.43，P = 0.007）和第四四分位数（OR = 1.96，P < 0.001）的参与者患高血压的几率显着增加。高血压的 OR 随血清 corin 水平呈正向且显着增加（趋势 P < 0.001）。进一步的亚组分析显示，与高corin（血清corin中位水平以上：1,689.20 pg/ml）相关的高血压的OR在按年龄、体重指数、总胆固醇、低密度脂蛋白胆固醇和空腹血糖分组的亚组中仍然显着（均P < 0.05）。结论我们的研究表明，与非高血压参与者相比，高血压参与者的血清corin水平升高。这一发现表明 Corin 可能在高血压的病理学中发挥作用。
BACKGROUNDCorin has been suggested to be associated with hypertension by cell- and animal-based studies. However, the association still lacks population-based evidence which critically promotes translation from basic research to clinical and preventive practice. Here, we aimed to explore the association in a general population of China.METHODSFrom January to May 2010, we conducted a cross-sectional study in 2,498 participants aged above 30 years, residing in Gusu district of Suzhou. Serum soluble corin and blood pressure were measured.RESULTSHypertensive participants had a higher level of serum corin than nonhypertensive participants (median (interquartile range): 1,836.83 (1,497.85-2,327.87) pg/ml vs. 1,579.14 (1,322.18-1,956.82) pg/ml, P < 0.001). Higher serum corin was positively associated with prevalent hypertension (odds ratio (OR) = 2.01, P < 0.001). In the multiple analysis, participants in the third (OR = 1.43, P = 0.007) and fourth (OR = 1.96, P < 0.001) quartiles had significantly increased odds of hypertension compared to those in the lowest quartile of serum corin. ORs of hypertension positively and significantly increased with serum corin levels (P for trend < 0.001). Further subgroup analysis showed that ORs of hypertension associated with high corin (over the median level of serum corin: 1,689.20 pg/ml) were still significant in subgroups by age, body mass index, total cholesterol, low-density lipoprotein cholesterol, and fasting plasma glucose (all P < 0.05).CONCLUSIONSOur study showed that hypertensive participants had an increased serum corin level compared to those without hypertension. This finding suggests that corin may play a role in the pathology of hypertension.