Incidence of Increased 68Ga-DOTANOC Uptake in the Pancreatic Head in a Large Series of Extrapancreatic NET Patients Studied with Sequential PET/CT
Incidence of Increased 68Ga-DOTANOC Uptake in the Pancreatic Head in a Large Series of Extrapancreatic NET Patients Studied with Sequential PET/CT
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DOI：
10.2967/jnumed.111.088328
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发表时间：
2011-06-01
影响因子：
9.3
通讯作者：
Fanti, Stefano
中科院分区：
文献类型：
--
作者：
Castellucci, Paolo;Ucha, Javier Pou;Fanti, Stefano
我们回顾性研究的目的是通过一系列Ga-68-DOTANOC PET/CT研究大量胰腺外神经内分泌肿瘤患者，评估胰腺头部Ga-68-DOTANOC摄取增加的发生率。方法：在一段时间内接受过至少两次Ga-68-DOTANOC PET/CT检查的患者被纳入。测量胰腺头部的摄取，并与正常肝实质的摄取（靶肝比）进行比较。患者随访6-24个月。结果：我们回顾了对100例患者进行的245项研究，并将胰腺摄取分为弥漫性或局灶性。23例患者（66次扫描）显示弥漫性摄取；8例（16次扫描）显示局灶性摄取。这31名患者在随后的扫描中均未发现阴性结果，反之亦然。在随访中，没有任何患者怀疑神经内分泌肿瘤定位于胰腺。结论：胰腺头部Ga-68-DOTANOC的局灶性摄取和弥漫性摄取分别发生在23%和8%的患者中。我们研究的主要发现是胰腺摄取的增加随着时间的推移是稳定的。
The aim of our retrospective study was to assess the incidence of increased uptake of Ga-68-DOTANOC in the head of the pancreas among a large population of patients with extrapancreatic neuroendocrine tumors studied with serial Ga-68-DOTANOC PET/CT. Methods: Patients who had undergone at least two Ga-68-DOTANOC PET/CT studies over time were included. Uptake in the head of the pancreas was measured and compared with uptake in normal liver parenchyma (target-to-liver ratio). Patients were followed up for 6-24 mo. Results: We reviewed 245 studies performed on 100 patients and classified the pancreatic uptake as either diffuse or focal. Twenty-three patients (66 scans) showed diffuse uptake; 8 patients (16 scans) showed focal uptake. None of these 31 patients had negative findings on their subsequent scans, and vice versa. During follow-up, localization of neuroendocrine tumors in the pancreas was not suspected in any patient. Conclusion: Focal and diffuse uptake of Ga-68-DOTANOC in the head of the pancreas occurred, respectively, in 23% and 8% of the patients. The main finding of our study was that increased pancreatic uptake was stable over time.