The toxicity of cyanobacterial toxins in the mouse: I Microcystin-LR
The toxicity of cyanobacterial toxins in the mouse: I Microcystin-LR
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DOI：
10.1191/096032799678839842
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发表时间：
1999-03-01
影响因子：
2.8
通讯作者：
Hill, RE
中科院分区：
文献类型：
--
作者：
Fawell, JK;Mitchell, RE;Hill, RE
蓝藻或蓝藻的水华可引起鱼类、水禽、动物和人中毒，引起这种中毒的毒素之一是肝毒素微囊藻毒素-LR，它被发现存在于家庭供水水源中间歇出现的水华中。本研究通过三组实验研究微囊藻毒素-LR对小鼠和大鼠的急性毒性、对小鼠胚胎发育的潜在影响以及小鼠连续13周口服给药的影响，结果如下：(1)微囊藻毒素-LR经口摄入的毒性是腹腔注射的30-100倍；(2)微囊藻毒素-LR在小鼠体内不是一种选择性发育毒物。对于任何形式的发育毒性，妊娠6-15天每天给予600微克·公斤(-1)体重没有观察到的不良反应水平(NOAEL)：(3)对于肝脏组织损伤，每天40微克·公斤(-1)体重的微囊藻毒素-LR有明显的不良反应。根据这一数据，1微囊藻毒素L(-1)-LR的值将是一个适当的饮用水指导值。
Blooms of cyanobacteria or blue-green algae are known to have caused poisoning in fish, waterfowl, animals and man, One of the toxins responsible for this is the hepatotoxin microcystin-LR which has been found to occur in blooms present intermittently in sources used for domestic water supplies. Three sets of experiments were undertaken to investigate the acute toxicity of microcystin-LR in mice and rats by the oral and intraperitoneal routes, the potential for effects on foetal development in the mouse, and the effects of repeated oral dosing over 13 weeks in the mouse, The results of this work were as follows: (1) Microcystin-LR is 30-100 times less toxic via oral ingestion than via intraperitoneal injection; (2) Microcystin-LR is not a selective developmental toxicant in the mouse. There was a No Observed Adverse Effect Level (NOAEL) of 600 mu g kg(-1) bodyweight per day given on days 6-15 of pregnancy for any form of developmental toxicity; (3) There was a clear NOAEL for tissue damage in the liver of 40 mu g kg(-1) bodyweight per day of microcystin-LR. Using this data, a value of 1 mu g l(-1) microcystin-LR would be an appropriate guideline value for drinking water.