Nephrotic syndrome due to primary AL amyloidosis, successfully treated with VAD and subsequent high-dose melphalan followed by autologous peripheral blood stem cell transplantation.
Nephrotic syndrome due to primary AL amyloidosis, successfully treated with VAD and subsequent high-dose melphalan followed by autologous peripheral blood stem cell transplantation.
复制标题
由原发性 AL 淀粉样变性引起的肾病综合征，通过 VAD 和随后的大剂量美法仑以及自体外周血干细胞移植成功治疗。
作者：
T. Gono;M. Matsuda;N. Dohi;K. Hoshi;T. Tada;K. Sakashita;K. Koike;Masatsugu Aizawa;S. Ikeda
原发性AL淀粉样变性从疾病的早期阶段就累及重要器官，导致预后不良。我们报告了一例因这种类型的淀粉样变性而患肾病综合征的患者，他成功地接受了两个疗程的VAD（长春新碱，多柔比星和地塞米松）和随后的大剂量美法仑（140 mg/m2）与自体干细胞支持治疗。连续化疗后，他的蛋白尿得到改善，血清和尿液中的M蛋白检测不到。为避免原发性AL淀粉样变的进展，在一般状况和重要器官功能良好的情况下，应积极使用强化化疗。
Primary AL amyloidosis involves vital organs from the early phase of illness, resulting in a poor prognosis. We report a patient with nephrotic syndrome due to this type of amyloidosis, who was successfully treated with two courses of VAD (vincristine, doxorubicin and dexamethasone) and subsequent high-dose melphalan (140 mg/m2) with autologous stem cell support. Following the serial chemotherapy his proteinuria improved, and M protein became undetectable in both serum and urine. To avoid the progression of primary AL amyloidosis, intensive chemotherapy should be actively used when the general status and vital organ functions are well preserved.
高剂量美法仑自体移植治疗肾衰竭的安全性：药代动力学和毒性研究。
DOI：
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发表时间：
1996
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research.
影响因子：
--
作者：
Tricot,G;Alberts,DS;Johnson,C;Roe,DJ;Dorr,RT;Bracy,D;Vesole,DH;Jagannath,S;Meyers,R;Barlogie,B
通讯作者：
Barlogie,B
目前多发性骨髓瘤的治疗。
DOI：
10.2169/internalmedicine.41.175
发表时间：
2002
期刊：
Internal medicine (Tokyo, Japan)
影响因子：
--
作者：
Kyle,RobertA
通讯作者：
Kyle,RobertA
影响因子：
3.6
作者：
R. Kyle;M. Gertz
通讯作者：
R. Kyle;M. Gertz