Animal models of contraception: utility and limitations.
Animal models of contraception: utility and limitations.
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DOI：
10.2147/oajc.s58754
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发表时间：
2015
影响因子：
2.1
通讯作者：
Bell JD
中科院分区：
文献类型：
--
作者：
Liechty ER;Bergin IL;Bell JD
适当的动物模型对于成功开发新型避孕装置至关重要。生殖生物学的进步已经确定了避孕干预的新途径。在这里，我们回顾了影响临床前避孕试验的物种特异性解剖和生理因素，包括疗效测试，机理研究，器械设计和脱靶效应建模。重点放在使用非人灵长类动物模型在避孕装置的发展。
Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.