Effect of three loading doses of warfarin on the international normalized ratio for dogs
Effect of three loading doses of warfarin on the international normalized ratio for dogs
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DOI：
10.2460/ajvr.2000.61.48
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发表时间：
2000-01-01
影响因子：
1
通讯作者：
Morgan, MR
中科院分区：
文献类型：
--
作者：
Monnet, E;Morgan, MR
评价3种负荷剂量的华法林钠对犬的国际标准化比值（INR）的影响。动物-18只体重在25和30 kg之间的犬。程序-犬随机分为3组，在双侧髂动脉移植手术后，每天一次口服给予2、4或6 mg华法林，持续2天。治疗前后测定活化部分凝血活酶（APTT）和凝血酶原时间（PT）。凝血酶原时间也被报道为国际标准化ratio. Results-APTT治疗前后组间无显着差异。治疗后两组INR、PT均明显升高。6 mg组的INR和PT显著大于2 mg和4 mg组。没有一只狗有临床证据的bleeding.Conclusions和临床相关性华法林负荷剂量为6毫克/天，可以安全地管理2天之间的狗体重25和30公斤。使用华法林可在2天内安全地在犬中实现抗凝。华法林的作用可以通过INR进行监测。
Objective-To evaluate effect of 3 loading doses of warfarin sodium on the international normalized ratio (INR) for dogs.Animals-18 dogs weighing between 25 and 30 kg.Procedure-Dogs were randomly allocated into 3 groups and received 2, 4, or 6 mg of warfarin administered orally once a day for 2 days after surgery for bilateral iliac artery grafting. Activated partial thromboplastin (APTT) and prothrombin times (PT) were measured before and after treatment. Prothrombin time also was reported as an international normalized ratio.Results-The APTT were not significantly different among groups before or after treatment. The INR and PT were significantly increased in ail groups after treatment. The INR and PT of the 6-mg group were significantly greater than those of the 2-mg and 4-mg groups. None of the dogs had clinical evidence of bleeding.Conclusions and Clinical Relevance-A warfarin loading dose of 6 mg/d can be safely administered for 2 days to dogs weighing between 25 and 30 kg. Anticoagulation can be achieved safely in dogs in 2 days by use of warfarin. The effects of warfarin can be monitored with the INR.