Concordance Between BeamF3 and MRI-neuronavigated Target Sites for Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex.
Concordance Between BeamF3 and MRI-neuronavigated Target Sites for Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex.
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DOI：
10.1016/j.brs.2015.05.008
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发表时间：
2015-09
影响因子：
7.7
通讯作者：
Downar J
中科院分区：
文献类型：
--
作者：
Mir-Moghtadaei A;Caballero R;Fried P;Fox MD;Lee K;Giacobbe P;Daskalakis ZJ;Blumberger DM;Downar J
背外侧前额叶皮层（DLPFC）是重性抑郁症患者重复经颅磁刺激（rTMS）的常见靶点，但传统的"5 cm规则"在> 1/3的病例中遗漏了DLPFC。另一个启发式算法BeamF3根据头皮测量定位F3 EEG位点。MRI引导的神经导航更繁琐，但可以直接靶向特定的DLPFC立体定位坐标。这两种方法之间的一致性以前没有被评估过。量化BeamF3与MRI引导神经导航治疗左侧DLPFC的头皮部位差异。使用来自接受左侧DLPFC-rTMS的受试者的100个治疗前MRI，我们将头皮部位定位在距我们先前工作中得出的目标MNI坐标（X-38 Y +44 Z +26）的最小欧几里得距离处。我们对相同受试者的MRI进行了鼻根-枕隆凸、耳屏-耳屏和头围测量，并应用了BeamF3启发式。然后，我们比较了BeamF3和MRI引导的头皮部位之间的距离。50%的受试者的BeamF3与MRI引导的差异<0.65 cm，75%的受试者的差异<0.99 cm，95%的受试者的差异<1.36 cm。使用MRI引导与BeamF3方法，中线到头皮部位的角度无显著差异。然而，MRI引导下从顶点到靶部位的径向弧长度略长于BeamF3（平均0.35 cm）。在大多数受试者中，BeamF3启发式可以为MRI引导的神经导航定位左侧DLPFC提供合理的近似值。对启发式算法的小优化可能会产生额外的一致性。
The dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) in major depression, but the conventional “5 cm rule” misses DLPFC in > 1/3 cases. Another heuristic, BeamF3, locates the F3 EEG site from scalp measurements. MRI-guided neuronavigation is more onerous, but can target a specific DLPFC stereotaxic coordinate directly. The concordance between these two approaches has not previously been assessed. To quantify the discrepancy in scalp site between BeamF3 versus MRI-guided neuronavigation for left DLPFC. Using 100 pre-treatment MRIs from subjects undergoing left DLPFC-rTMS, we localized the scalp site at minimum Euclidean distance from a target MNI coordinate (X − 38 Y + 44 Z + 26) derived from our previous work. We performed nasion-inion, tragus–tragus, and head-circumference measurements on the same subjects’ MRIs, and applied the BeamF3 heuristic. We then compared the distance between BeamF3 and MRI-guided scalp sites. BeamF3-to-MRI-guided discrepancies were <0.65 cm in 50% of subjects, <0.99 cm in 75% of subjects, and <1.36 cm in 95% of subjects. The angle from midline to the scalp site did not differ significantly using MRI-guided versus BeamF3 methods. However, the length of the radial arc from vertex to target site was slightly but significantly longer (mean 0.35 cm) with MRI-guidance versus BeamF3. The BeamF3 heuristic may provide a reasonable approximation to MRI-guided neuronavigation for locating left DLPFC in a majority of subjects. A minor optimization of the heuristic may yield additional concordance.