Congenital rubella syndrome and physical growth: a 17-year, prospective, longitudinal follow-up in the Ryukyu Islands.
Congenital rubella syndrome and physical growth: a 17-year, prospective, longitudinal follow-up in the Ryukyu Islands.
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先天性风疹综合征和身体生长：在琉球群岛进行的 17 年前瞻性纵向随访。
DOI：
10.1093/clinids/8.6.874
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Hisanaga
中科院分区：
文献类型：
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作者：
K. Tokugawa;Kohji Veda;J. Fukushige;T. Koyanagi;S. Hisanaga
对日本南部琉球群岛1965年风疹疫情后出生的363名先天性风疹综合征(CRS)儿童的生长发育进行了前瞻性跟踪调查，年龄从2岁到17岁。与其他CRS儿童相比，白内障儿童的生长发育明显迟缓(身高和体重都是如此)；后者的生长(身高和体重)与学龄前普通健康人群的生长几乎相同，尽管所有CRS儿童在学龄前都很小。所有CRS儿童的头围都比对照组儿童小，其中白内障组最小。数据表明，被认为在怀孕60天之前接触母体临床风疹的儿童至少在17岁之前发育不佳，而那些被认为在怀孕60天后感染风疹的儿童从早期学龄开始恢复正常生长模式。
The growth of 363 children who were born with congenital rubella syndrome (CRS) after the 1965 rubella epidemic in the Ryukyu Islands in southern Japan was followed prospectively from two through 17 years of age. The growth of children with cataract was obviously retarded (in terms of both height and body weight) when compared with that of other CRS children; the growth of the latter group (height and weight) was almost the same as that of the general healthy population by school age, although all CRS children were small in the preschool years. All children with CRS had smaller head circumferences than control children, with the smallest for the cataract group. The data indicate that children supposedly exposed to maternal clinical rubella before the 60th day of gestation grew poorly at least until the age of 17 years, whereas those supposedly infected after the 60th day began to return to a normal growth pattern from early school age.