Nutritional "Omics" technologies for elucidating the role(s) of bioactive food components in colon cancer prevention
Nutritional "Omics" technologies for elucidating the role(s) of bioactive food components in colon cancer prevention
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DOI：
10.1093/jn/135.11.2694
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发表时间：
2005-11-01
影响因子：
4.2
通讯作者：
Hord, NG
中科院分区：
文献类型：
--
作者：
Davis, CD;Hord, NG
继续有证据表明，饮食成分和遗传易感性是癌症风险和肿瘤行为的重要决定因素。具有相似饮食模式的人群中癌症发病率的差异表明，个体的反应可能反映了与遗传因素的相互作用，这可能会改变基因、蛋白质和代谢物的表达模式。营养基因组学被定义为营养和个人基因组之间的相互作用，可能会提供关于应答者和非应答者的重要线索。在这次研讨会中，生物活性食品成分在结肠癌易感性中的作用被用来举例说明“基因组”技术在癌症预防中的应用。讨论的主题包括饮食变化和基因多态(营养遗传学)、DNA甲基化(营养表观基因组学)、基因表达(营养转录学)、蛋白质的改变形成或生物激活(蛋白质组学)，以及暴露的数量和时间如何影响小分子细胞成分(代谢组学)。最后的发言集中在脱落细胞作为评价癌症预防中生物活性食品成分的替代样本。研讨会的目标是为每一种与营养、癌症风险和肿瘤行为相关的“基因组”技术提供一个范例，并帮助与会者理解，需要一个同时审查所有“基因组”技术的综合框架。
Evidence continues to implicate dietary components and genetic susceptibilities as important determinants of cancer risk and tumor behavior. Variation in cancer incidence among and within populations with similar dietary patterns suggests that an individual's response may reflect interactions with genetic factors, which may modify gene, protein, and metabolite expression patterns. Nutrigenomics, defined as the interaction between nutrition and an individual's genome, will likely provide important clues about responders and norresponders. In this symposium, the role of bioactive food components in colon cancer susceptibility was used to exemplify the application of "omic" technologies for cancer prevention. Topics that were addressed included dietary changes and gene polymorphisms (nutrigenetics), DNA methylation (nutritional epigenomics), gene expression (nutritional transcriptomics), altered formation or bioactivation of proteins (proteomics), and characterizing how the quantity and timing of exposure influence small molecular weight cellular constituents (metabolomics). The final presentation focused on exfoliated cells as a surrogate sample for the evaluation of bioactive food components in cancer prevention. The goal of the symposium was to provide an example of each of the "omic" technologies as they relate to nutrition, cancer risk, and tumor behavior, and to help the participants understand that an integrated framework that simultaneously examines all of the "omic" technologies is needed.