CORRELATIONS BETWEEN STIFFNESS AND CHEMICAL CONSTITUENTS OF CARTILAGE ON HUMAN FEMORAL HEAD
CORRELATIONS BETWEEN STIFFNESS AND CHEMICAL CONSTITUENTS OF CARTILAGE ON HUMAN FEMORAL HEAD
复制标题
DOI：
10.1016/0304-4165(70)90388-0
复制
发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
FREEMAN, MAR
中科院分区：
文献类型：
--
作者：
KEMPSON, GE;MUIR, H;FREEMAN, MAR
本文概述了一种在体外测量人股骨头关节软骨压缩刚度的方法。测量垂直于关节表面的压痕，并根据这些测量结果计算出施加载荷后2秒的蠕变模数。测定了硬挺度与以下指标的相关性：(1)总糖胺多糖含量，(2)硫酸软骨素含量，(3)硫酸角蛋白含量，(4)胶原蛋白含量。这些数量是通过对软骨凹陷区的化学分析确定的，并以干重的百分比表示。观察到：以蠕变模数表示的硬度与总糖胺多糖含量之间存在统计上的显著相关性。硬度与硫酸软骨素和硫酸角蛋白含量之间的相关系数基本相等，但在一定浓度下，硫酸角蛋白对硬度的影响大于硫酸软骨素。相比之下，硬度和胶原蛋白含量之间的相关性要小得多。
A method is described, in outline, for measuring the compressive stiffness of articular cartilage on the human femoral head,in vitro. Indentations were measured normal to the articular surface, and from these measurements creep moduli were calculated at 2 sec after application of the load. Correlations between the stiffness and the following quantities were determined: (1) Total glycosaminoglycan content, (2) chondroitin sulphate content, (3) ‘keratin sulphate’ content, and (4) collagen content. These quantities were determined from chemical analyses of the indented areas of cartilage and expressed as a percentage of the dry weight.The following observations were made: there was a statistically significant correlation between the stiffness, expressed as the creep modulus, and the total glycosaminoglycan content. Approximately equal correlation coefficients were recorded between the stiffness and chondroitin sulphate and ‘keratan sulphate’ content respectively; however, at a given concentration, the influence of ‘keratin sulphate’, on the stiffness, was greater than that of chondroitin sulphate. In contrast, the correlation between stiffness and collagen content was considerably less significant.