Pregnancy in Sickle Cell Disease Is a Very High-Risk Situation: An Observational Study.
Pregnancy in Sickle Cell Disease Is a Very High-Risk Situation: An Observational Study.
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DOI：
10.1155/2016/9069054
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发表时间：
2016
影响因子：
1.9
通讯作者：
Carles G
中科院分区：
文献类型：
--
作者：
Elenga N;Adeline A;Balcaen J;Vaz T;Calvez M;Terraz A;Accrombessi L;Carles G
镰状细胞病是一种严重的遗传性疾病，影响法属圭亚那1/235的新生儿。本研究旨在描述卡宴医院镰状细胞病患者的妊娠随访，以突出报道最多的并发症。研究人员分析了2007年至2013年期间44名镰状细胞病女性的62份妊娠记录。我们的研究结果进行了比较，在巴西和瓜德罗普进行的研究。有61例单胎妊娠和2例双胎妊娠，27例SS表型妊娠，30例SC妊娠和5例S-β妊娠。研究表明，患者的随访是可变的，但没有发现产妇死亡。我们还注意到，主要的妊娠母胎并发症是贫血（36.5%），感染（31.7%），血管闭塞危象其中先兆子痫占17.5%，早产占11.1%，胎儿宫内发育迟缓占15.9%，胎心异常占14.3%，死胎占4.8%。SS表型的妇女怀孕的风险更大。镰状细胞病患者的妊娠需要多学科团队的支持，包括初级保健医生，产科医生和镰状细胞病综合中心。
Sickle cell disease is a serious genetic disorder affecting 1/235 births in French Guiana. This study aimed to describe the follow-up of pregnancies among sickle cell disease patients in Cayenne Hospital, in order to highlight the most reported complications. 62 records of pregnancies were analyzed among 44 females with sickle cell disease, between 2007 and 2013. Our results were compared to those of studies conducted in Brazil and Guadeloupe. There were 61 monofetal pregnancies and 2 twin pregnancies, 27 pregnancies among women with SS phenotype, 30 SC pregnancies, and five S-beta pregnancies. The study showed that the follow-up of patients was variable, but no maternal death was found. We also noted that the main maternofetal complications of pregnancies were anemia (36.5%), infection (31.7%), vasoocclusive crisis (20.6%), preeclampsia (17.5%), premature birth (11.1%), intrauterine growth retardation (15.9%), abnormal fetal heart rate (14.3%), and intrauterine fetal death (4.8%). Pregnancies were more at risk among women with SS phenotype. Pregnancy in sickle cell disease patients requires a supported multidisciplinary team including the primary care physician, the obstetrician, and the Integrated Center for Sickle Cell Disease.