Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
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DOI：
10.1016/j.drugalcdep.2005.09.011
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发表时间：
2006-04-28
影响因子：
4.2
通讯作者：
Renshaw, PF
中科院分区：
文献类型：
--
作者：
Hwang, J;Lyoo, IK;Renshaw, PF
背景：本研究的目的是探讨短期和长期戒除甲基苯丙胺（MA）使用者的相对局部脑血流量（rCBF）的变化。方法：通过锝-99m-六甲基丙烯胺肟（Tc-99m-HMPAO）单光子发射计算机断层扫描（SPECT）比较40名戒除甲基苯丙胺（MA）使用者和23名健康对照受试者的相对rCBF。还对短期（< 6 个月）和长期（>= 6 个月）戒断的 MA 使用者组中发现显着差异的区域的相对 rCBF 进行了比较。 结果：与健康对照受试者相比，MA 使用者的右前扣带皮层（布罗德曼区 32）的相对 rCBF 降低。长期禁欲的 MA 使用者的 rCBF 显着高于短期禁欲的 MA 使用者。结论：我们报告说，禁欲的 MA 使用者的前扣带皮层的 rCBF 降低，而长期禁欲的受试者的相对降低幅度较小。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Background: The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users.Methods: Relative rCBF in 40 abstinent MA users and 23 healthy comparison subjects was compared by the technetium-99m-hexamethylpropylene amine oxime (Tc-99m-HMPAO) single photon emission computed tomography (SPECT). Relative rCBF in areas that were found to differ significantly was also compared in groups of MA users with short-term (< 6 months) and long-term ( >= 6 months) abstinence.Results: MA users showed decreased relative rCBF in the right anterior cingulate cortex (Brodmann area 32) relative to healthy comparison subjects. Long-term abstinent MA users had significantly greater rCBF than short-term abstinent MA users.Conclusions: We report that abstinent MA users have decreased rCBF in the anterior cingulate cortex with smaller relative decreases in subjects with prolonged abstinence. (c) 2005 Elsevier Ireland Ltd. All rights reserved.