The chronological change of vertebral bone loss following oophorectomy using dual energy X-ray absorptiometry: The correlation with specific markers of bone metabolism
The chronological change of vertebral bone loss following oophorectomy using dual energy X-ray absorptiometry: The correlation with specific markers of bone metabolism
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DOI：
10.1016/0378-5122(95)00940-m
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发表时间：
1995-11-01
期刊：
影响因子：
4.9
通讯作者：
Nakano, H
中科院分区：
文献类型：
--
作者：
Hashimoto, K;Nozaki, M;Nakano, H
采用双能 X 射线骨密度测定法 (DEXA) 对 38 名绝经前妇女和 244 名卵巢切除妇女进行了卵巢切除术后椎骨骨密度 (BMD; g/cm(2)) 的变化研究。同时还测量了骨重塑的两项生化指标，即用于骨吸收的尿脱氧吡啶啉（DPyr）和用于骨形成的血清完整人骨钙素（hOC）。卵巢切除术后第一年骨丢失率为10.7%，第二年骨丢失率为5.7%（快速期），随后是缓慢期，骨丢失率为1.1%。卵巢切除术后12年，骨量终于达到骨质疏松水平（BMD < 0.767 g/cm(2)）。 DPyr在术后第一年增加并达到峰值，而hOC在术后第二年增加并达到峰值。第一年的最大骨丢失被认为是由于骨吸收的显着增加和骨形成最大增加的生物延迟造成的。
The changes of vertebral bone mineral density (BMD; g/cm(2)) following oophorectomy were studied, using dual energy X-ray absorptiometry (DEXA) in 38 premenopausal and 244 oophorectomized women. Two biochemical indices of bone remodeling, urinary deoxypyridinoline (DPyr) for bone resorption and serum intact human osteocalcin (hOC) for bone formation, were also measured at the same time. The rate of bone loss in the first year after oophorectomy was 10.7%, while that in the second year was 5.7% (rapid phase), followed by a slow phase at the rate of 1.1%. The bone mass finally reached an osteoporotic level (BMD < 0.767 g/cm(2)) at 12 years after oophorectomy. The DPyr increased to reach a peak level in the first year, whereas the hOC increased and reached its peak level in the second year after surgery. The maximal bone loss in the first year is considered to be caused by the remarkable increase of bone resorption and the biological delay of the maximal increase in bone formation.