Incidence of Second Metachronous Head and Neck Cancers: Population-Based Outcomes Over 25 Years
Incidence of Second Metachronous Head and Neck Cancers: Population-Based Outcomes Over 25 Years
复制标题
DOI：
10.1002/lary.24719
复制
发表时间：
2014-10-01
期刊：
影响因子：
2.6
通讯作者：
Olson, Robert A.
中科院分区：
文献类型：
--
作者：
Tiwana, Manpreet S.;Hay, John;Olson, Robert A.
Objectives/HypothesisThe primary objective was to determine the incidence of second metachronous head and neck cancers（HNC）after a index HNC and estimate their overall survival.Study DesignRetrospective cohort study.MethodsA total of 1，658 continuous primary HNC patients diagnosed in 1986 to 1990 were identified through the prospectively maintained provincial BC Cancer Registry database.他们被随访了25年。生存分析和第二个癌症估计进行了标准的Kaplan-Meier &考克斯回归analysis.ResultsOut的443（27%）第二个癌症，89（5%）第二HNC发生在1,658 HNC患者，精算异时HNC发病率在5，10，15，20，25年，分别为3.9%，8.1%，10.4%，13.2%和14.5%。第二原发癌（SPC）发生在肺和食管分别为155（9%）和32（2%）例。所有患者和存活患者的中位随访时间分别为4.05年（范围，0.2-25.0年）和23.2年（范围，20.76-25.0年）。第二次HNC中，83例（93%）为异时性。口腔（P
Objectives/HypothesisThe primary objective was to determine the incidence of second metachronous head and neck cancers (HNC) following an index HNC and estimate their overall survival.Study DesignRetrospective cohort study.MethodsA total of 1,658 consecutive primary HNC patients diagnosed in 1986 to 1990 were identified through the prospectively maintained provincial BC Cancer Registry database. They were followed up for a period of 25 years. Survival analysis and second cancer estimates were performed with standard Kaplan-Meier & Cox regression analysis.ResultsOut of a total of 443 (27%) second cancers, 89 (5%) second HNC occurred in 1,658 HNC patients, with an actuarial metachronous HNC incidence rate at 5, 10, 15, 20, and 25 years that was 3.9%, 8.1%, 10.4%, 13.2%, and 14.5%, respectively. Second primary cancer (SPC) in lung and esophagus occurred in 155 (9%) and 32 (2%) patients, respectively. The median follow-up time for all patients and alive patients was 4.05 years (range, 0.2-25.0 years) and 23.2 years (range, 20.76-25.0 years), respectively. Of second HNC, 83 (93%) were metachronous. Oral cavity (P