Maintenance of maternal diet-induced hypertension in the rat is dependent on glucocorticoids
Maintenance of maternal diet-induced hypertension in the rat is dependent on glucocorticoids
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DOI：
10.1161/01.hyp.30.6.1525
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发表时间：
1997-12-01
期刊：
影响因子：
8.3
通讯作者：
Langley-Evans, SC
中科院分区：
文献类型：
--
作者：
Gardner, DS;Jackson, AA;Langley-Evans, SC
最近的流行病学证据表明，成人心血管风险由出生体重和影响出生体重的因素（例如母亲营养）决定。来自动物模型的数据表明，营养和糖皮质激素“程序”之间的相互作用会增加成人高血压的风险。胎儿对母体糖皮质激素的暴露增加是由于胎盘对母体糖皮质激素（11β-羟基类固醇脱氢酶）的屏障减少而发生的，建议对糖皮质激素治疗的大鼠和母体蛋白质限制的大鼠产生的后代进行高血压。产后糖皮质激素刺激可能影响蛋白质限制大鼠后代高血压进展的程度在 6 周大的雄性 Wistar 大鼠中进行了评估，这些大鼠产前暴露于 18% 酪蛋白（对照）或 9% 酪蛋白（低蛋白）饮食。对每个饮食组的大鼠进行假手术、肾上腺切除术或肾上腺切除术，并每天用20mg皮质酮/kg体重进行治疗。手术前，低蛋白暴露大鼠的收缩压显着高于对照组（165+/-3.8 与 142+/-3.3 mm Hg，P
Recent epidemiological evidence suggests that adult cardiovascular risk is determined by birth weight and factors that influence birth weight, such as maternal nutrition. Data from animal models suggest that an interaction between nutrition and glucocorticoid hormones "programs" increased risk of adult hypertension. Increased fetal exposure to maternal glucocorticoids that is proposed to occur from a reduction in the placental barrier to maternal glucocorticoid, 11 beta-hydroxysteroid dehydrogenase, is suggested to program hypertension in the resultant offspring from both glucocorticoid-treated and maternally protein-restricted rats. The extent to which postnatal glucocorticoid stimulation may influence the progression of hypertension in the offspring from protein-restricted rat darns was assessed in 6-week-old male Wistar rats, prenatally exposed to either an 18% casein (control) or 9% casein (low protein) diet. Rats from each dietary group were sham operated, adrenalectomized or adrenalectomized, and treated with 20 mg corticosterone/kg body weight per day. Before surgery, systolic blood pressure was significantly higher in the low protein-exposed rats compared with controls (165+/-3.8 versus 142+/-3.3 mm Hg, P