Nidogens -: Extracellular matrix linker molecules
Nidogens -: Extracellular matrix linker molecules
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DOI：
10.1002/jemt.20567
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Smyth, Neil
中科院分区：
文献类型：
--
作者：
Ho, Matthew S. P.;Boese, Kerstin;Smyth, Neil
巢蛋白/内陷蛋白是高度保守的硫酸化糖蛋白家族。生物化学研究表明它们在基底膜中具有重要的结构作用。然而，尽管是这种专门的细胞外基质的普遍存在的成分，并具有广泛的结合伴侣，遗传分析表明，它们不是基底膜的整体结构所必需的。相反，在发育过程中，它们在其稳定中起重要作用，特别是在经历快速生长或周转的组织中。巢蛋白的破坏是乳腺退化过程中基底膜降解的关键事件。一些研究，最令人信服的是C。elegans的研究表明，巢蛋白可能具有其他非结构性作用，并参与轴突寻路和突触传递。
Nidogens/entactins are a family of highly conserved, sulfated glycoproteins. Biochemical studies have implicated them as having a major structural role in the basement membrane. However despite being ubiquitous components of this specialized extracellular matrix and having a wide spectrum of binding partners, genetic analysis has shown that they are not required for the overall architecture of the basement membrane. Rather in development they play an important role in its stabilization especially in tissues undergoing rapid growth or turnover. Nidogen breakdown has been implicated as a key event in the basement membrane degradation occurring in mammary gland involution. A number of studies, most compellingly those in C. elegans, demonstrated that nidogens may have other nonstructural roles and be involved in axonal pathfinding and synaptic transmission.