ZBTB7A links tumor metabolism to myeloid differentiation
ZBTB7A links tumor metabolism to myeloid differentiation
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DOI：
10.1016/j.exphem.2020.05.010
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发表时间：
2020-07-01
影响因子：
2.6
通讯作者：
Greif, Philipp A.
中科院分区：
文献类型：
--
作者：
Monte, Enric Redondo;Kerbs, Paul;Greif, Philipp A.
ZBTB 7A是一种转录因子，调节造血分化的所有三个分支，同时抑制关键糖酵解酶和葡萄糖转运蛋白的表达。在这里，我们提出ZBTB 7A作为分化和代谢，两个相互关联的细胞过程之间的联系。特别是，ZBTB 7A可以激活或抑制特定细胞谱系分化所必需的代谢程序，同时控制关键途径，如Notch信号传导。最后，ZBTB 7A的双重作用对骨髓恶性肿瘤的治疗具有意义，其中分化的阻断可能通过具有低毒性的代谢疗法来克服。(C)2020 ISEH -血液学和干细胞学会。爱思唯尔公司出版
ZBTB7A is a transcription factor that regulates all three branches of hematopoietic differentiation while repressing the expression of key glycolytic enzymes and glucose transporters. Here, we propose that ZBTB7A acts as a link between differentiation and metabolism, two interconnected cellular processes. In particular, ZBTB7A can activate or repress metabolic programs necessary for the differentiation of specific cell lineages while controlling key pathways such as Notch signaling. Finally, the dual role of ZBTB7A has implications for the treatment of myeloid malignancies, where the block of differentiation could potentially be overcome by metabolic therapies with low toxicity. (C) 2020 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc.