A general CD-method for the configurational assignment of erythro-8.4'-oxyneolign-8'-enes
A general CD-method for the configurational assignment of erythro-8.4'-oxyneolign-8'-enes
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DOI：
10.3998/ark.5550190.0005.d09
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发表时间：
2004-11
期刊：
影响因子：
0.9
通讯作者：
K. Kónya;T. Kurtán;A. Kiss-Szikszai;L. Juhász;S. Antus
中科院分区：
文献类型：
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作者：
K. Kónya;T. Kurtán;A. Kiss-Szikszai;L. Juhász;S. Antus
Resolution of erythro-7-hydroxy-3′,5′-dimethoxy-3,4-methylenedioxy-8.4′-oxyneolign-8′-ene 1c was achieved by preparing the diastereomeric esters with (–)-(R)-α-methoxyphenylacetic acid. The correlation of its CD properties with the absolute configuration established a general CD method for the configurational assignment of erythro-8.4′-oxyneolignenes: positive Cotton effects of the two low-energy CD transitions derive from 7R,8S configuration while the negative ones from 7S,8R. This rule allows the configurational assignment of erythro-8.4′-oxyneolignenes with different aromatic substitution pattern by a CD measurement.
