An Anti-Biofouling Flexible Fiber Biofuel Cell Working in the Brain
An Anti-Biofouling Flexible Fiber Biofuel Cell Working in the Brain
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DOI：
10.1002/smtd.202200142
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发表时间：
2022-03-23
期刊：
影响因子：
12.4
通讯作者：
Peng, Huisheng
中科院分区：
文献类型：
--
作者：
Guo, Yue;Chen, Chuanrui;Peng, Huisheng
生物燃料电池（BFC）将化学能转化为电能，是一种很有前途的植入式电子能量收集装置。然而，对于可植入BFC仍然存在主要挑战，包括与诸如大脑的软组织不匹配的庞大且刚性的装置结构，以及由于生物环境中的结垢过程而导致的功率输出降低。在这里，开发了一种长期在大脑中工作的柔性抗生物污染纤维BFC。纤维BFC基于碳纳米管纤维电极，具有小尺寸和柔性。在纤维BFC表面设计了一层亲水性的两性离子抗生物污损聚多巴胺-2-甲基丙烯酰氧乙基磷酰胆碱层，以抵抗复杂生物环境中蛋白质的非特异性吸附。植入后，纤维BFC可实现稳定的装置/组织界面，沿着可忽略的免疫应答。光纤BFC在小鼠脑中首次实现了一个多月的发电，显示了其作为体内能量收集装置的良好前景。
Biofuel cell (BFC) that transfers chemical energy into electricity is a promising candidate as an energy-harvesting device for implantable electronics. However, there still remain major challenges for implantable BFCs, including bulky and rigid device structure mismatching with soft tissues such as the brain, and the power output decreases due to the fouling process in a biological environment. Here, a flexible and anti-biofouling fiber BFC working in the brain chronically is developed. The fiber BFC is based on a carbon nanotube fiber electrode to possess small size and flexibility. A hydrophilic zwitterionic anti-biofouling polydopamine-2-methacryloyloxyethyl phosphorylcholine layer is designed on the surface of fiber BFC to resist the nonspecific protein adsorption in a complex biological environment. After implantation, the fiber BFC can achieve a stable device/tissue interface, along with a negligible immune response. The fiber BFC has first realized power generation in the mouse brain for over a month, exhibiting its promising prospect as an energy-harvesting device in vivo.