Longitudinal changes and regional variation of incident infection rates at cystic fibrosis centers, United States 2010-2016
Longitudinal changes and regional variation of incident infection rates at cystic fibrosis centers, United States 2010-2016
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DOI：
10.1016/j.jcf.2021.08.009
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发表时间：
2022-01-01
影响因子：
5.2
通讯作者：
Saiman, Lisa
中科院分区：
文献类型：
--
作者：
Muhlebach, Marianne S.;Jiang, Xiaotong;Saiman, Lisa
背景资料：多种因素影响CF护理中心铜绿假单胞菌（PA）和耐甲氧西林金黄色葡萄球菌（MRSA）的事件感染率（IIR）。我们评估了在时间上与2013年感染/预防和控制指南控制center-specific factors.Methods：使用CF基金会患者登记，我们定义和测量IIR的变化之间的变化CF中心IIR 2010-2012和2014-2016。将数据与地理位置相似地区的MRSA和耐药PA的非CF率进行比较。每个CF中心的特征（n个中心：2010年成人54例至2016年82例）。儿科-106）和他们各自的人口进行了评估与IIR和IIR的变化之间的研究periods.Results：在多年的35613例患者。PA（平均19.2 +/- 0.04%儿科，21.2 +/- 0.07%成人中心）的感染率高于MRSA（平均9.4 +/- 0.03%儿科，7.8 +/- 0.03%成人）。MRSA的IIR降低（-1.54 +/-0.54%，p
Background: Multiple factors affect incident infection rates (IIR) for Pseudomonas aeruginosa (PA) and methicillin resistant Staphylococcus aureus (MRSA) at CF care centers. We assessed changes in IIR across CF centers temporally associated with the 2013 Infection/Prevention & Control guidelines controlling for center-specific factors.Methods: Using the CF Foundation Patient Registry we defined and measured changes in IIR between 2010-2012 and 2014-2016. Data were compared to non-CF rates of MRSA and resistant PA in geographically similar regions. Characteristics of each CF center (n centers: Adult 54 in 2010 to 82 in 2016. Pediatric -106) and their respective population were evaluated for associations with IIR and with changes in IIR between the study periods.Results: Across the years 35613 patients were included. Incident-infection rates for PA (mean 19.2 +/- 0.04% Pediatric, 21.2 +/- 0.07% Adult centers) were higher than for MRSA (mean 9.4 +/- 0.03% Pediatric, 7.8 +/- 0.03% Adult). The IIR decreased for MRSA (-1.54 +/- 0.54%, p