Branch architecture of the fly larval abdominal serotonergic neurons
Branch architecture of the fly larval abdominal serotonergic neurons
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DOI：
10.1016/j.ydbio.2008.03.038
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发表时间：
2008-08-01
影响因子：
2.7
通讯作者：
Condron, Barry G.
中科院分区：
文献类型：
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作者：
Chen, John;Condron, Barry G.
在后生动物中枢神经系统（CNS）中，突触能神经元在整个突触神经元中发送投射。关于这些广泛的神经调节分支模式的规则知之甚少。在这项研究中，我们利用果蝇作为一个模型来研究多巴胺能分支。使用单细胞GFP标记，我们表明，在果蝇腹神经索（VNC）的每一段内的两个多巴胺能神经元瓷砖不同的神经支配模式，在对侧神经元。此外，分支仅从目标段延伸很短的距离。通过消融介导的分离的肾上腺素能细胞，我们表明，不同的区域的神经支配不通过相邻的肾上腺素能神经突起之间的竞争来维持。此外，尽管初始轴突轨迹发生了变化，但神经元内轴突能神经元的基本分支模式保持不变。(C)2008年爱思唯尔公司All rights reserved.
In the metazoan central nervous system (CNS), serotonergic neurons send projections throughout the synaptic neuropil. Little is known about the rules that govern these widespread neuromodulatory branching patterns. In this study, we utilize the Drosophila as a model to examine serotonergic branching. Using single cell GFP labeling we show that within each segment of the Drosophila ventral nerve Cord (VNC) each of two serotonergic neurons tiles distinct innervation patterns in the contralateral neuropil. I addition, branches extend only a short distance from the target segment. Through ablation-mediated isolation of serotonergic cells, we demonstrate that the distinct areas of innervation are not maintained through competition between neighboring like-serotonergic neurites. Furthermore, the basic branching pattern of serotonergic neurons within the neuropil remains unchanged despite alterations of initial axonal trajectories. (C) 2008 Elsevier Inc. All rights reserved.