5α-Reductase inhibition activity of steroids isolated from marine soft corals
5α-Reductase inhibition activity of steroids isolated from marine soft corals
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DOI：
10.1016/j.steroids.2004.04.001
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发表时间：
2004-07-01
期刊：
影响因子：
2.7
通讯作者：
García, G
中科院分区：
文献类型：
--
作者：
Radhika, P;Cabeza, M;García, G
本研究的目的是通过测定壳青霉发酵液中[H-3]T到[H-3]DHT的转化率来确定几个新的甾体化合物PR-01-PR-07的5α-还原酶抑制活性。这些化合物是从霍里、纳特卡尔和卡利普尔群岛的安达曼和尼科巴海岸采集的海洋软珊瑚中获得的，经鉴定为Sinularia grailobata Verseveldt、Sinularia crassa Tixier-Durivault、Sinularia gravis Tixier-Durault、Sinularia sp.、LobPhytom sp.。Crassum和Cladiella sp.PR-01-PR-04显著抑制[H-3]T向[H-3]DHT的转化(P<；而PR-05和PR-06在该模型中无明显差异(P>；0.05)。另一方面，PR-07刺激(P<；0.05)酶反应。(C)2004 Elsevier Inc.保留所有权利。
The aim of this study is to determine the 5alpha-reductase inhibitory activity of several new steroidal compounds PR-01-PR-07 by measuring the conversion of [H-3]T to [H-3]DHT in Penicillium crustosum broths.These compounds were obtained from marine soft corals collected on the coasts of Andaman and Nicobar at Hori, Natkal and Kalipur (Diglipur) Islands and identified as Sinularia grandilobata Verseveldt, Sinularia crassa Tixier-Durivault, Sinularia gravis Tixier-Durivault, Sinularia sp., Lobophytum sp., Lobophytum crassum and Cladiella sp.PR-01-PR-04 significantly inhibited the conversion of [H-3]T to [H-3]DHT (P < 0.05) whereas PR-05 and PR-06 did not show an appreciable difference (P > 0.05) in this model. On the other hand PR-07 stimulated (P < 0.05) the enzymatic reaction. (C) 2004 Elsevier Inc. All rights reserved.