Proton MR spectroscopy of the basal ganglia in healthy children and children with AIDS.
Proton MR spectroscopy of the basal ganglia in healthy children and children with AIDS.
复制标题
健康儿童和艾滋病儿童基底神经节的质子磁共振波谱。
作者：
Dongfeng Lu;S. G. Pavlakis;S. G. Pavlakis;Yitzchak Frank;Yitzchak Frank;Saroj Bakshi;Saroj Bakshi;Savita Pahwa;Savita Pahwa;Robert J. Gould;Robert J. Gould;Cristina Sison;Cristina Sison;Ching Hsu;Ching Hsu;Martin Lesser;Martin Lesser;Mara Hoberman;Tracy Barnett;R. A. Hyman;R. A. Hyman
目的
PURPOSE
To evaluate proton magnetic resonance (MR) spectroscopy in children with the acquired immunodeficiency syndrome (AIDS) and to establish an age-dependent spectroscopic database of the normal basal ganglia in children.
MATERIALS AND METHODS
Eighteen healthy children and 45 children with AIDS underwent both brain MR imaging and single-voxel MR spectroscopy with a long-echo-time point-resolved technique. A large part of the region of interest studied at MR spectroscopy included the basal ganglia.
RESULTS
Seven patients with progressive encephalopathy and eight with static encephalopathy had significantly lower mean N-acetyl aspartate (NAA)/creatine (Cr) ratios than age-matched control subjects (P<.02). In determining the presence of progressive encephalopathy in children with AIDS, MR spectroscopy appears to be more sensitive and specific than MR imaging and immunologic testing. Thirty patients without encephalopathy had normal NAA/Cr ratios but significantly lower choline/Cr ratios than age-matched control subjects (P<.02).
CONCLUSION
Proton MR spectroscopy may be a more sensitive diagnostic technique than MR imaging in childhood AIDS encephalopathy.