An Analysis of Resistance Patterns of Oral Streptococci Obtained from Orofacial Infections Against Beta-lactams, Clindamycin and Vancomycin over 2014-2018
An Analysis of Resistance Patterns of Oral Streptococci Obtained from Orofacial Infections Against Beta-lactams, Clindamycin and Vancomycin over 2014-2018
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DOI：
10.3290/j.ohpd.a43165
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发表时间：
2019-11-01
影响因子：
1.6
通讯作者：
Mlynarczyk, Grazyna
中科院分区：
文献类型：
--
作者：
Leszczynski, Piotr;Sokol-Leszczynska, Beata;Mlynarczyk, Grazyna
目的：比较翠绿菌群链球菌（VGS）对青霉素、氨苄西林、克林霉素和万古霉素的敏感性，以确定耐药率，评估预防性或治疗性抗生素治疗指南是否包括目前的耐药模式。材料与方法：回顾性分析779株VGS分离株（累积数据）连续4年（2014-2017年）和2018年4个月的药敏试验（AST）结果。分离株来源于口腔颌面部感染患者的脓液和颌面部手术患者的组织碎片。结果：对克林霉素耐药率最高。副鳗链球菌（Streptococcus paranguinis）和星座链球菌（S. constellatus）的总耐药率分别为43%和49%；最小的是S. anginosus，为12%。所有分离株在试验期间均对氨苄西林敏感。所有菌株在研究期间均对万古霉素敏感。结论：由于耐药水平较高，应强制进行个体药敏试验。
Purpose: Comparison of viridans group Streptococcus (VGS) susceptibility to benzylpenicillin, ampicillin, clindamycin and vancomycin in order to determine resistance rates to assess whether guidelines for prophylactic or therapeutic antibiotic treatment include the present resistance patterns.Materials and Methods: A retrospective analysis of antimicrobial susceptibility testing (AST) over 4 consecutive years (2014-2017) and 4 months in 2018 for 779 VGS isolates (cumulative data). Isolates originated from pus from orofacial infections cases and tissue fragments from patients undergoing maxillofacial surgeriesResults: The highest resistance rate was observed to clindamycin. The highest overall resistance rate was for Streptococcus parasanguinis 43% and S. constellatus 49%; the lowest was for S. anginosus 12%. All S. anginosus isolates were susceptible to ampicillin during tested period. All isolates of analysed species were susceptible to vancomycin through studied period.Conclusion: Due to high resistance levels, individual antibiotic susceptibility testing for strains should become mandatory.