Occult carcinoma in prophylactic oophorectomy specimens - Prevalence and association with BRCA germline mutation status
Occult carcinoma in prophylactic oophorectomy specimens - Prevalence and association with BRCA germline mutation status
复制标题
DOI：
10.1097/00000478-200110000-00009
复制
发表时间：
2001-10-01
影响因子：
5.6
通讯作者：
Rosen, B
中科院分区：
文献类型：
--
作者：
Colgan, TJ;Murphy, J;Rosen, B
预防性卵巢切除术（PO）是卵巢癌风险增加的女性的一种选择，在这项研究中，PO标本和伴随的切除组织的强化病理检查在识别隐匿性癌中的价值以及隐匿性癌与BRCA生殖细胞突变状态的任何相关性被确定。在一项为期8年的前瞻性研究中，对60例连续PO患者的标本进行了标准化的完整病理学检查，这些患者在手术时未被怀疑患有任何卵巢肿瘤。卵巢外组织也进行了检查，但它们不受相同的标准化协议。观察到卵巢或输卵管的任何隐匿性癌。获得患者的BRCA状态和随访（如可用）。60份PO标本中有55份未显示任何恶性肿瘤证据。本组32例患者随访1年以上，均存活良好。其余5例患者均为BRCA 1突变阳性，表现为卵巢隐匿性癌和/或输卵管原位癌或浸润性癌。这五名患者中有一名死于腹部癌病;四名患者仍然很好，但随访时间很长。
Prophylactic oophorectomy (PO) is an option for women at increased risk for ovarian carcinoma, In this study the value of intensive pathologic examination of PO specimens and accompanying resected tissues in the identification of occult carcinoma and any association of occult carcinoma with BRCA germline mutation status were ascertained. Specimens from 60 consecutive PO patients, who were not suspected of having any ovarian tumor at the time of surgery, were subjected to standardized, complete pathologic examination in a prospective study over an 8-year period. Extra-ovarian tissues were examined as well, but they were not subject to the same standardized protocol. Any occult carcinoma of the ovaries or fallopian tubes was noted. The BRCA status and follow-up of patients were obtained, if available. Fifty-five of the 60 PO specimens did not show any evidence of malignancy. Of the 32 patients in this group followed for >1 year, all are alive and well. The remaining five patients, all BRCA1 mutation positive, showed occult carcinoma of the ovaries and/or in situ or invasive carcinoma of a fallopian tube. One of these five patients has died of abdominal carcinomatosis; four continue to be well, but follow-up is