Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets
Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets
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DOI：
10.1016/j.canlet.2011.11.026
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发表时间：
2012-04-28
期刊：
影响因子：
9.7
通讯作者：
Soria, Claudine
中科院分区：
文献类型：
--
作者：
Gest, Caroline;Mirshahi, Pezhman;Soria, Claudine
Seeking to improve ovarian cancer therapy, we compared biological characteristics of the moderately-aggressive OVCAR-3 cell line with two highly aggressive ovarian cancer cell populations: the SK-OV-3 cell line, and HASCJ primary cells isolated from the ascitic fluid of a patient with FIGO stage IV ovarian cancer. Secretion of angiogenic factors was not discriminative, whereas cell invasion through Matrigel and vasculogenic mimicry were much greater in the more aggressive cells. Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
